Hepatic artery-infusion chemotherapy improved survival of hepatocellular carcinoma after radical hepatectomy

Figures & data

Table 1 Baseline characteristics

	Control (n=43)	HAIC (n=42)	P-value
Age (years)	58.4±5.7	59.1±6.2	0.5892
AFP (ng/mL)	547.5±49.2	562.4±54.1	0.1875
Tumor size (cm)	5.7±1.3	6.2±1.5	0.1041
Operating time (minutes)	187.2±44.1	178.4±47.6	0.379
Blood loss in operation (mL)	478.4±87.6	492.5±108.9	0.512
Sex			0.6789
Male	30	31
Female	13	11
Microvascular invasion			0.4172
Positive	25	28
Negative	18	14
Etiology			0.8844
HBV	24	25
HCV	7	8
Alcohol	7	6
Others	5	3
Cirrhosis			0.9008
Absent	10	9
Mild	22	20
Severe	11	13
Resection modalities			0.7132
Single segmentectomy	14	12
Multiple segmentectomies	20	18
Lobectomy	9	12
Tumor number			0.4766
Single	24	23
Multiple	18	20
Tumor differentiation			0.7531
Good	10	12
Moderate	12	14
Poor	20	17
Child–Pugh stage			0.5951
A	27	24
B	16	18

Note: Data presented as number or mean ± standard deviation.

Abbreviations: AFP, alpha fetoprotein; HAIC, hepatic artery-infusion chemotherapy; HBV, hepatitis B virus; HCV, hepatitis C virus.

Figure 1 Intrahepatic recurrence-free survival curves after radical hepatectomy.

Notes: In the first 5 postoperative years, 23 of 42 patients in the HAIC group and 29 of 43 in the control group developed intrahepatic recurrence. The HAIC group obtained significantly higher intrahepatic recurrence-free survival probability (HR 0.5615, 95% CI 0.3234–0.9749; P=0.0332).
Abbreviation: HAIC, hepatic artery-infusion chemotherapy.

Figure 2 Disease-free survival curves after radical hepatectomy.

Notes: In the first 5 postoperative years, 29 patients in the HAIC group developed recurrence compared with 36 patients in the control group. The 5-year disease-free survival probability was significantly higher in the HAIC group than in the control group (HR 0.591, 95% CI 0.3613–0.9666, P=0.0298).
Abbreviation: HAIC, hepatic artery-infusion chemotherapy.

Figure 3 Overall survival curves after radical hepatectomy.

Notes: In the first 5 postoperative years, 27 patients in the HAIC group and 34 patients in the control group had died. The HAIC group obtained significantly higher overall survival probability than the control group (HR 0.5768, 95% CI 0.3469–0.9589; P=0.0278).
Abbreviation: HAIC, hepatic artery-infusion chemotherapy.