Current advances of long non-coding RNA highly upregulated in liver cancer in human tumors

Figures & data

Table 1 Functions and applications of upregulated HULC in various tumors

Tumor types	Expression	Functions	Applications	References
HCC	Up	Proliferation, apoptosis, invasion, metastasis, tumorigenesis	Staging biomarker, diagnostic biomarker, prognostic indicator, therapeutic target	^Citation14,Citation26,Citation27,Citation31^–^Citation33
GC	Up	Proliferation, apoptosis, suppression, invasion, metastasis, EMT	Staging biomarker, diagnostic biomarker, prognostic indicator, therapeutic target	^Citation10,Citation37
CRC	Up	Proliferation, apoptosis, migration, invasion, metastasis, tumorigenesis	Diagnostic biomarker, prognostic indicator, therapeutic target	^Citation11,Citation43
PC	Up	Proliferation, invasion, metastasis	Staging biomarker, diagnostic biomarker, prognostic indicator, therapeutic target	^Citation48
OS	Up	Proliferation, migration, invasion, metastasis	Staging biomarker, diagnostic biomarker, prognostic indicator, therapeutic target	^Citation12,Citation54
DLBCL	Up	Proliferation, apoptosis, suppression	Diagnostic biomarker, prognostic indicator, therapeutic target	^Citation13
Glioma	Up	Proliferation, adhesion, migration, invasion, angiogenesis	Diagnostic biomarker, prognostic indicator, therapeutic target	^Citation13,Citation57

Abbreviations: HULC, highly upregulated in liver cancer; HCC, hepatocellular carcinoma; GC, gastric cancer; EMT, epithelial–mesenchymal transition; CRC, colorectal cancer; PC, pancreatic cancer; OS, osteosarcoma; DLBCL, diffuse large B-cell lymphoma.

Figure 1 The protumorigenic mechanisms of HULC overexpression in HCC and CRC.

Notes: (A) HULC could promote cancer development through regulatory pathways in HCC. (B) Summary diagram describes that HULC regulates CRC cell proliferation.
Abbreviations: HULC, highly upregulated in liver cancer; HCC, hepatocellular carcinoma; CRC, colorectal cancer; CREB, cAMP response element binding; SPHK1, sphingosine kinase 1; ZEB1, zinc finger E-box-binding homeobox 1; EMT, epithelial–mesenchymal transition; EZH2, enhancer of zeste homolog 2.

SanulliSJustinNTeissandierAJarid2 methylation via the PRC2 complex regulates H3K27me3 deposition during cell differentiationMol Cell201557576978325620564

 PubMed Web of Science ®Google Scholar

ZhuQLiNZengXHepatocellular carcinoma in a large medical center of China over a 10-year period: evolving therapeutic option and improving survivalOncotarget2015664440445025686836

 PubMedGoogle Scholar

MaluccioMCoveyARecent progress in understanding, diagnosing, and treating hepatocellular carcinomaCA Cancer J Clin201262639439923070690

 PubMed Web of Science ®Google Scholar

WanDShenSFuSmiR-203 suppresses the proliferation and metastasis of hepatocellular carcinoma by targeting oncogene ADAM9 and oncogenic long non-coding RNA HULCAnticancer Agents Med Chem201616441442326179263

 PubMed Web of Science ®Google Scholar

WangRSunQWangPNotch and Wnt/beta-catenin signaling pathway play important roles in activating liver cancer stem cellsOncotarget2016755754576826735577

 PubMedGoogle Scholar

JinCShiWWangFLong non-coding RNA HULC as a novel serum biomarker for diagnosis and prognosis prediction of gastric cancerOncotarget2016732517635177227322075

 PubMedGoogle Scholar

SakaMMoritaSFukagawaTKataiHPresent and future status of gastric cancer surgeryJpn J Clin Oncol201141330731321242182

 PubMed Web of Science ®Google Scholar

YangXJHuangCQPengCWHouJXLiuJYLong noncoding RNA HULC promotes colorectal carcinoma progression through epigenetically repressing NKD2 expressionGene2016592117217827496341

 PubMed Web of Science ®Google Scholar

FungKYNiceEPriebeIColorectal cancer biomarkers: to be or not to be? Cautionary tales from a road well travelledWorld J Gastroenterol201420488889824574763

 PubMed Web of Science ®Google Scholar

PengWGaoWFengJLong noncoding RNA HULC is a novel biomarker of poor prognosis in patients with pancreatic cancerMed Oncol2014311234625412939

 PubMed Web of Science ®Google Scholar

UzanVRLengertABoldriniEHigh expression of HULC is associated with poor prognosis in osteosarcoma patientsPLoS One2016116e156774

 PubMed Web of Science ®Google Scholar

SunXHYangLBGengXLWangRZhangZCIncreased expression of lncRNA HULC indicates a poor prognosis and promotes cell metastasis in osteosarcomaInt J Clin Exp Pathol2015832994300026045809

 PubMed Web of Science ®Google Scholar

PengWWuJFengJLong noncoding RNA HULC predicts poor clinical outcome and represents pro-oncogenic activity in diffuse large B-cell lymphomaBiomed Pharmacother20167918819327044827

 PubMed Web of Science ®Google Scholar

ZhuYZhangXQiLHULC long noncoding RNA silencing suppresses angiogenesis by regulating ESM-1 via the PI3K/Akt/mTOR signaling pathway in human gliomasOncotarget2016712144291444026894862

 PubMedGoogle Scholar