Impact of hypertrophic pulmonary osteoarthropathy on patients with lung cancer

Figures & data

Table 1 Clinical characteristics of lung cancer patients with HPOA

Characteristics	Male N=56 (%)	Female N=13 (%)	Total N=69
Smoker
Never	7 (12.5)	11 (84.6)	18
Ex- or current	49 (87.5)	2 (15.4)	51
Histology
Adenocarcinoma	35 (62.5)	7 (53.8)	42
Squamous cell carcinoma	11 (19.6)	1 (7.7)	12
Others	10	5	15
Adenosquamous	4 (7.1)	2 (15.4)	6
Large-cell carcinoma	3 (5.3)	2 (15.4)	5
Sarcomatoid carcinoma	2 (3.6)	1 (7.7)	3
Small-cell carcinoma	1 (1.8)	0 (0)	1
Clinical stage
I	0 (0)	1 (7.7)	1
II	5 (8.9)	1 (7.7)	6
IIIa	6 (10.7)	1 (7.7)	7
IIIb	7 (12.5)	1 (7.7)	8
IV	38 (67.9)	9 (69.2)	47
EGFR	26	8	34
Wild type	23 (88.5)	6 (75)	29
Exon 20 insertion	1 (3.8)	0 (0)	1
Eonx 21 L858R	2 (7.7)	0 (0)	2
Exon 19 deletion	0 (0)	2 (25)	2

Abbreviations: HPOA, hypertrophic pulmonary osteoarthritis; EGFR, epidermal growth factor receptor.

Table 2 Treatment outcome of HPOA patients with EGFR sensitive mutation

No	Gender	Age	EGFR	Stage	TKIs	PFS (m)	OS (m)
1	Female	77	L858R	Ib	Gefitinib	2.5	36.0*
2	Female	53	Exon 19 deletion	IV	Gefitinib	5.9	52.6
3	Male	68	Exon 19 deletion	IIIb	Erlotinib	8.2	29.0

Note:

* From cancer recurrence to patient deceased.

Abbreviations: (m), months; No, number; EGFR, epidermal growth factor receptor; HPOA, hypertrophic pulmonary osteoarthropathy; TKIs, tyrosine kinase inhibitors; PFS, progression-free survival; OS, overall survival.

Table 3 Characteristics of lung cancer patients with HPOA in previous studies

Author	Year	N	Incidence	Male	Smoker	Adenocarcinoma histology	EGFR M+
This study	2017	69	1.28%	81.2%	73.9%	60.8%	11.8%
Qian and Qin^Citation18	2014	115	1.87%	91%	76%	48%	NM
Ito et al^Citation2	2010	19	0.72%	89.4%	94.7%	52.6%	NM
Izumi et al^Citation19	2010	55	4.5%	70.9%	NM	45%	NM
Morgan et al^Citation3	1996	28	17%	78.5%	NM	17%	NM
Segal and Mackenzie^Citation20	1982	16	0.8%	68.8%	100%	38%	NM

Abbreviations: N, patient numbers; EGFR, epidermal growth factor receptor; M+, with sensitive mutation; NM, not mentioned.

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