Figures & data
Notes: A total of 12 samples were analyzed. According to the final pathological diagnosis of 12 samples, the first, second, and fifth were M1; the third, sixth, seventh, and ninth were M2; and the remaining were M3. Seven cases showed moderate to strong IGF2BP3 expression, and five cases showed negative to weak expression. The relative expression of proteins was normalized to GAPDH.
Abbreviations: GAPDH, glyceraldehyde 3-phosphate dehydrogenase; HGIN, high-grade intraepithelial neoplasia; IGF2BP3, insulin-like growth factor-II mRNA-binding protein-3.
Abbreviations: GAPDH, glyceraldehyde 3-phosphate dehydrogenase; HGIN, high-grade intraepithelial neoplasia; IGF2BP3, insulin-like growth factor-II mRNA-binding protein-3.
Notes: All images were captured at 200× magnification. Positive (A) and negative (B) staining of IGF2BP3 in pT1a-EP (M1). Positive (C) and negative (D) staining of IGF2BP3 in pT1a-LPM (M2). Positive (E) and negative (F) staining of IGF2BP3 in pT1a-MM (M3). Positive staining of IGF2BP3 was characterized by a dark brown staining in the cytoplasm of the neoplastic cells.
Abbreviations: HGIN, high-grade intraepithelial neoplasia; IGF2BP3, insulin-like growth factor-II mRNA-binding protein-3; IHC, immunohistochemistry.
Abbreviations: HGIN, high-grade intraepithelial neoplasia; IGF2BP3, insulin-like growth factor-II mRNA-binding protein-3; IHC, immunohistochemistry.