Clinicopathological significance of HSP27 in gastric cancer: a meta-analysis

Figures & data

Figure 1 Flowchart of study selection.

Table 1 Characteristics of studies included in the meta-analysis

Author	Year	Country	No of patients	Expression: cancer (+/−), control (+/−)	Lymph node metastasis: metastasis (+/−), non-metastasis (+/−)	Serosal invasion: yes (+/−), no (+/−)	Gender: male (+/−), female (+/−)	Tumor size: ≤5 cm (+/−), >5 (+/−)	Differentiation: low (+/−) high and moderate (+/−)	TNM: I, II (+/−) III, IV (+/−)	Quality score
Kapranos et al^Citation15	2002	Greece	86	54/32 68/18	48/23 6/9	NA	25/19 29/13	32/17 22/15	NA	12/12 42/20	9
Li et al^Citation24	2010	China	45	31/14 12/38	18/11 13/3	21/11 10/3	15/8 16/6	NA	22/5 9/9	NA	8
Hu et al^Citation25	2015	China	75	48/27 23/52	32/9 16/18	NA	35/18 13/9	23/23 25/4	32/9 16/18	23/21 25/6	9
Li^Citation26	2015	China	48	31/17 1/13	29/10 2/7	28/10 3/7	NA	16/10 15/7	NA	7/6 24/11	7
Lu et al^Citation27	2007	China	68	32/36 15/42	10/15 22/21	8/11 24/25	18/19 14/17	NA	4/11 28/25	NA	7
Liu^Citation28	2014	China	118	71/47 32/86	50/25 32/11	46/16 36/20	57/27 25/9	NA	37/21 46/14	49/18 34/17	9
Tang et al^Citation29	2009	China	34	18/16 4/30	NA	NA	NA	NA	NA	NA	6
Xiao^Citation30	2014	China	90	77/13 47/43	51/8 26/5	NA	24/9 53/4	NA	NA	NA	7
Shang et al^Citation31	2012	China	60	44/16 6/54	30/13 14/3	28/10 16/6	31/12 13/4	NA	30/16 6/8	18/12 17/13	7

Abbreviation: NA, not available.

Figure 2 Forest plot of studies evaluating the relationship between HSP27 expression and clinicopathological features: (A) expression; (B) lymph node metastasis; (C) serosal invasion; (D) gender; (E) tumor size; (F) differentiation; (G) TNM stage.

Note: Weights are from random effects analysis.
Abbreviations: OR, odds ratio; CI, confidence interval.

Table 2 HSP27 clinicopathological features for gastric carcinoma

Clinicopathological features	Heterogeneity
	No of studies	No of patients	Pooled OR (95% CI)	PHet	I^2 (%)	P-value	Model used
Expression	9	624	4.73 (2.22–10.05)	0.000	86.5	0.000	Random
Lymph node metastasis	8	590	1.32 (0.64–2.72)	0.003	67.1	0.453	Random
Serosal invasion	5	339	1.31 (0.81–2.12)	0.147	41.2	0.267	Fixed
Gender	7	542	0.73 (0.50–1.08)	0.377	6.7	0.120	Fixed
Tumor size	3	209	0.56 (0.16–1.91)	0.022	73.7	0.354	Random
Differentiation	5	366	1.47 (0.51–4.22)	0.001	78.3	0.473	Random
TNM stage	5	387	0.70 (0.46–1.08)	0.108	47.2	0.111	Fixed

Abbreviations: Random, random effects model; Fixed, fixed effects model; OR, odds ratio; CI, confidence interval.

Figure 3 Begg’s publication bias plot for HSP27 related studies: (A) expression; (B) lymph node metastasis; (C) serosal invasion; (D) gender; (E) tumor size; (F) differentiation; (G) TNM stage.

Abbreviations: SE, standard error; OR, odds ratio.

Table 3 Subgroup analysis of expression, lymph node metastasis, tumor size, and differentiation

Subgroups	No of studies	No of patients	Pooled OR (95% Cl)	PHet	I^2 (%)	P-value
Expression
Sample size
≤60	4	187	12.15 (6.12–24.13)	0.260	25.2	0.000
>60	5	437	2.51 (1.05–6.01)	0.000	88.2	0.039
Lymph node metastasis
Sample size
≤60	3	153	1.17 (0.17–8.07)	0.008	79.2	0.873
>60	5	437	1.42 (0.66–3.08)	0.023	64.6	0.370
Tumor size
Sample size
≤60	1	48	0.75 (0.23–2.45)	–	–	0.632
>60	2	161	0.47 (0.06–3.66)	0.006	86.8	0.473
Differentiation
Sample size
≤60	2	105	3.23 (1.31–7.96)	0.541	0.0	0.011
>60	3	261	0.90 (0.21–3.91)	0.002	84.2	0.892

Abbreviations: OR, odds ratio; CI, confidence interval; n, number of sample size.

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