Clinical significance of CMTM4 expression in hepatocellular carcinoma

Figures & data

Figure 1 The expression of CMTM4 in HCC tissues and adjacent nontumor tissues by immunohistochemistry (magnification, ×200).

Abbreviations: CMTM4, chemokine-like factor-like MARVEL transmembrane domain-containing family 4; HCC, hepatocellular carcinoma.

Table 1 CMTM4 expression in HCC tissues and adjacent non-tumor tissues

HCC tissues	Adjacent tissues		Total
	Positive	Negative
Positive	8	13	21
Negative	41	13	54
Total	49	26	75

Abbreviations: CMTM4, chemokine-like factor-like MARVEL transmembrane domain-containing family 4; HCC, hepatocellular carcinoma.

Table 2 Association between the expression of CMTM4 and clinicopathological features of HCC

Variables	n	CMTM4		χ^2	P-value
		Positive	Negative
Sex				0.508	0.476
Male	61	16	45
Female	14	5	9
Age (years)				0.585	0.445
<50	34	11	23
≥50	41	10	31
Smoking status				2.818	0.093
Never	42	15	27
Ever	33	6	27
Alcohol use				0.861	0.353
Never	35	8	27
Ever	40	13	27
HBV infection				1.339	0.247
Negative	15	6	9
Positive	60	15	45
Tumor size (cm)				5.030	0.025
<5	38	15	23
≥5	37	6	31
Tumor number				2.083	0.149
1	40	14	26
≥2	35	7	28
Clinical stage				4.825	0.028
I + II	42	16	26
III + IV	33	5	28
TNM staging				4.240	0.039
T1 + T2	43	16	27
T3 + T4	32	5	27
Pathology classification				2.045	0.153
I + II	33	12	21
III	42	9	33
Liver cirrhosis				1.844	0.174
No	37	13	24
Yes	38	8	30
Metastasis				6.771	0.009
No	51	19	32
Yes	24	2	22
α-fetoprotein (ng/mL)				2.499	0.114
<400	32	12	20
≥400	43	9	34

Notes: Bold values indicate significance. P-values are based on the χ² test.

Abbreviations: CMTM4, chemokine-like factor-like MARVEL transmembrane domain-containing family 4; HBV, hepatitis B virus; HCC, hepatocellular carcinoma; TNM, tumor node metastasis.

Table 3 Multivariable logistic regression analysis of CMTM4 expression in HCC patients

Variables	B	Wald	P-value	ORa	95% CI for OR
					Lower	Upper
Metastasis	2.531	23.769	0.005	1.654	1.136	4.463
Tumor size	1.132	8.645	0.091	1.134	0.694	1.931

Notes:

a OR adjusted for age, sex, smoking status, alcohol use, and HBV infection.

Abbreviations: CI, confidence interval; CMTM4, chemokine-like factor-like MARVEL transmembrane domain-containing family 4; HBV, hepatitis B virus; HCC, hepatocellular carcinoma; OR, odds ratio.

Figure 2 Effect of the expression of CMTM4 on survival rates of HCC patients who underwent resection determined via Kaplan-Meier model analysis.

Abbreviations: CMTM4, chemokine-like factor-like MARVEL transmembrane domain-containing family 4; HCC, hepatocellular carcinoma.

Table 4 Multivariate analysis of influenced factors for overall survival of HCC patients after operation

Variables	B	Wald	P-value	OR	95% CI for OR
					Lower	Upper
CMTM4	0.897	4.043	0.041	2.433	1.075	5.786

Abbreviations: CI, confidence interval; CMTM4, chemokine-like factor-like MARVEL transmembrane domain-containing family 4; HCC, hepatocellular carcinoma; OR, odds ratio.