Advanced search
Publication Cover
OncoTargets and Therapy Volume 10, 2017 - Issue
Submit an article Journal homepage
64
Views
10
CrossRef citations to date
0
Altmetric
Original Research

Seven-microRNA panel for lung adenocarcinoma early diagnosis in patients presenting with ground-glass nodules

Yayi He1 Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, People’s Republic of China;2 Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
,
Yang Yang3 Department of Surgery, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine
,
Peng Kuang1 Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, People’s Republic of China
,
Shengxiang Ren1 Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, People’s Republic of China
,
Leslie Rozeboom2 Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
,
Christopher J Rivard2 Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
,
Xuefei Li4 Department of Lung Cancer and Immunology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, People’s Republic of China
,
Caicun Zhou1 Department of Medical Oncology, Shanghai Pulmonary Hospital, Tongji University Medical School Cancer Institute, Tongji University School of Medicine, Shanghai, People’s Republic of ChinaCorrespondence[email protected]
&
Fred R Hirsch2 Division of Medical Oncology, Department of Medicine, University of Colorado Anschutz Medical Campus, Aurora, CO, USA
 show all
Pages 5915-5926 | Published online: 13 Dec 2017

Figures & data

Table 1 Characteristics of 73 patients

Table 2 Participants’ characteristics with 66 lung benign diseases and 66 lung adenocarcinomas presenting with GGNs

Figure 1 Heat map of expression data of the 23 miRNAs.

Notes: Heat map of expression data of the 23 miRNAs found to be significantly differentially expressed by next-generation sequencing. The three left columns represent the three adenocarcinoma tumor samples from patients 1, 2 and 3, respectively, and the three columns on the right represent the three adjacent normal (N) paired tissues from patients 1, 2 and 3, respectively. High expression levels are depicted by red and low by blue.
Abbreviation: miRNAs, microRNAs.
Figure 1 Heat map of expression data of the 23 miRNAs.

Figure 2 AUC of 23 different microRNAs in tumor and non-tumor tissue by qRT-PCR.

Note: *P<0.05.
Abbreviations: AUC, area under the curve; miRNAs, microRNAs; qRT-PCR, quantitative real-time polymerase chain reaction.
Figure 2 AUC of 23 different microRNAs in tumor and non-tumor tissue by qRT-PCR.
Figure 2 AUC of 23 different microRNAs in tumor and non-tumor tissue by qRT-PCR.

Figure 3 miRNA target genes.

Note: Each network represents the interaction of a miRNA (yellow) and its target genes (blue).
Abbreviation: miRNA, microRNA.
Figure 3 miRNA target genes.
Figure 3 miRNA target genes.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.