Cytomembranic PD-L1 expression in locoregionally advanced nasopharyngeal carcinoma

Figures & data

Table 1 Patient characteristics

Characteristic	Cytomembrane high group (n=29)	Cytomembrane low group (n=56)	P-value
Sex			0.796
Male	21 (72.4)	42 (75.0)
Female	8 (27.6)	14 (25.0)
Age (yr)			0.880
≥47	15 (51.7)	28 (50.0)
<47	14 (48.3)	28 (50.0)
BMI (kg/m^2)			0.987
≥23	13 (44.8)	25 (44.6)
<23	16 (55.2)	31 (55.4)
T classification			0.217
T1	0 (0.0)	5 (8.9)
T2	4 (13.8)	5 (8.9)
T3	12 (41.4)	29 (51.8)
T4	13 (44.8)	17 (30.4)
N classification			0.616
N0	0 (0.0)	3 (5.4)
N1	9 (31.0)	15 (26.8)
N2	18 (62.1)	32 (57.1)
N3	2 (6.9)	6 (10.7)
Overall stage			0.513
III	16 (55.2)	35 (62.5)
IVA/B	13 (44.8)	21 (37.5)

Note: Data shown as n (%).

Abbreviation: BMI, body mass index.

Figure 1 Immunohistochemical staining for PD-L1 in patients with locoregionally advanced NPC.

Notes: (A) A patient whose tumor was considered low expression on immunohistochemical staining with cytomembranic PD-L1. (B) Another patient whose tumor was considered high expression on immunohistochemical staining with cytomembranic PD-L1.
Abbreviations: NPC, nasopharyngeal carcinoma; PD-L1, programmed death-ligand 1.

Figure 2 Kaplan–Meier curves stratified by the patterns of immunohistochemical staining for cytomembranic PD-L1 (low vs high).

Abbreviations: DFFS, distant failure-free survival; LFFS, local failure-free survival; OS, overall survival; PD-L1, programmed death-ligand 1; RFFS, regional failure-free survival.

Table 2 Impact of prognostic factors on treatment results by univariate analysis

Items	5y-LFFS		5y-RFFS		5y-DFFS		5y-OS
	%	P-value	%	P-value	%	P-value	%	P-value
Sex		0.480		0.757		0.177		0.467
Male	89.3		94.6		91.9		91.1
Female	95.5		95.2		100.0		95.2
Age (yr)		0.731		0.679		0.647		0.656
≥47	92.0		94.7		92.8		89.1
<47	89.7		94.9		95.2		95.1
BMI (kg/m^2)		0.872		0.786		0.844		0.345
≥23	91.2		94.3		94.6		93.9
<23	90.7		95.3		93.5		91.0
Overall stage		0.290		0.084		0.335		0.063
III	93.5		91.7		96.1		96.0
IVA/B	86.9		100.0		90.8		85.8
PD-L1		0.302		0.655		0.206		0.022
Cytomembrane high	96.2		96.3		89.7		82.5
Cytomembrane low	88.5		94.2		96.3		97.6

Abbreviations: BMI, body mass index; DFFS, distant failure-free survival; LFFS, local failure-free survival; PD-L1, programmed death-ligand 1; OS, overall survival; RFFS, regional failure-free survival.