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OncoTargets and Therapy Volume 11, 2018 - Issue
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Original Research

A 5-serum miRNA panel for the early detection of colorectal cancer

Shaohua Guo1 Chinese PLA Medical School, Beijing, China;2 General Surgery Department II, Chinese PLA General Hospital, Beijing, China
,
Jiajin Zhang2 General Surgery Department II, Chinese PLA General Hospital, Beijing, China
,
Baishi Wang2 General Surgery Department II, Chinese PLA General Hospital, Beijing, China
,
Bingdong Zhang1 Chinese PLA Medical School, Beijing, China
,
Xuning Wang1 Chinese PLA Medical School, Beijing, China
,
Liang Huang1 Chinese PLA Medical School, Beijing, China
,
Hongyi Liu2 General Surgery Department II, Chinese PLA General Hospital, Beijing, ChinaCorrespondence[email protected] [email protected]
&
Baoqing Jia1 Chinese PLA Medical School, Beijing, China;2 General Surgery Department II, Chinese PLA General Hospital, Beijing, ChinaCorrespondence[email protected] [email protected]
 show all
Pages 2603-2614 | Published online: 08 May 2018

Figures & data

Table 1 Clinical characteristics of patients

Figure 1 Study design.

Abbreviations: qRT-PCR, quantitative reverse transcription polymerase chain reaction; CRC, colorectal cancer; CRA, colorectal adenoma; HC, healthy control.
Figure 1 Study design.

Table 2 Different expression of microRNAs in individuals with colorectal cancer compared to healthy controls (screening stage)

Table 3 Different expression of microRNAs in individuals with colorectal cancer compared to colorectal adenoma (screening stage)

Figure 2 Validation stage, colorectal cancers compared to healthy controls.

Notes: Receiver operating characteristic curve analysis of miRNA-1246, miRNA-202-3p, miRNA-21-3p, miRNA-1229-3p, miRNA-532-3p, and the 5-serum miRNA panel.
Abbreviations: AUC, area under the curve; miRNA, microRNA.
Figure 2 Validation stage, colorectal cancers compared to healthy controls.
Figure 2 Validation stage, colorectal cancers compared to healthy controls.

Figure 3 Validation stage, colorectal cancers compared to colorectal adenomas.

Notes: Receiver operating characteristic curve analysis of miRNA-1246, miRNA-202-3p, miRNA-21-3p, miRNA-1229-3p, miRNA-532-3p and the 5-serum miRNA panel. Abbreviations: AUC, area under the curve; miRNA, microRNA.
Figure 3 Validation stage, colorectal cancers compared to colorectal adenomas.
Figure 3 Validation stage, colorectal cancers compared to colorectal adenomas.

Figure S1 The 5 microRNAs have different expression in the 3 groups.

Note: Created using https://cran.r-project.org/web/packages/pheatmap/index.html.
Abbreviations: CRA, colorectal adenoma; CRC, colorectal cancer; HC, healthy control.
Figure S1 The 5 microRNAs have different expression in the 3 groups.

Table S1 Different expression of microRNAs in individuals with colorectal cancer compared to colorectal adenoma (primary screening stage)

Table S2 Different expression of microRNAs in individuals with colorectal adenoma compared to healthy controls (primary screening stage)

Table S3 Different expression of microRNAs in individuals with colorectal cancer compared to healthy controls (primary screening stage)

Table S4 Different expression of microRNAs in individuals with colorectal adenoma compared to healthy controls (screening stage)

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