Potential clinical application of lncRNAs in non-small cell lung cancer

Figures & data

Table 1 lncRNAs related to NSCLC diagnosis

lncRNA	Diagnostic efficacy	Reference
MALAT1	Circulating MALAT1, AUC=0.79	^Citation21
	Exosomal MALAT1, AUC=0.703	^Citation22
GAS5	Circulating GAS5, AUC=0.832	^Citation25
	Combination of GAS5 and CEA, AUC=0.909
XIST and HIF1A-AS1	Circulating XIST, AUC=0.834	^Citation26
	Circulating HIF1A-AS1, AUC=0.876
	Combination of XIST and HIF1A-AS1, AUC=0.931
SPRY4-IT1, ANRIL, and NEAT1	Circulating SPRY4-IT1, AUC=0.603	^Citation27
	Circulating ANRIL, AUC=0.798
	Circulating NEAT1, AUC=0.693
	Combination of SPRY4-IT1, ANRIL, and NEAT1; AUC=0.876
SOX2OT and ANRIL	Circulating SOX2OT, AUC=0.745	^Citation28
	Circulating ANRIL, AUC=0.723
	Combination of SOX2OT, ANRIL, CEA, CYFRA21-1, and SCCA; AUC=0.853

Abbreviations: AUC, area under the receiver operating characteristic curve; NSCLC, non-small cell lung cancer; CEA, carcinoembryonic antigen.

Table 2 lncRNAs related to NSCLC prognosis

lncRNA	Function in NSCLC	Function	Reference
MALAT1	Promotes cell proliferation, migration, and invasion	Poor prognosis	^Citation55, ^Citation56
H19	Promotes cell growth	Poor prognosis	^Citation57
HOTAIR	Promotes cell proliferation, invasion, and metastasis	Poor prognosis	^Citation38, ^Citation58
CCAT2	Promotes cell proliferation and invasion	Poor prognosis	^Citation59
CARLo-5	Promotes cell proliferation, migration, and invasion	Poor prognosis	^Citation60
BANCR	Suppresses cell proliferation, induces apoptosis	Poor prognosis	^Citation61
PVT1	Promotes cell proliferation, migration, and invasion	Poor prognosis	^Citation62
ZXF1	Promotes cell invasion and metastasis	Poor prognosis	^Citation33
TUG1	Suppresses cell proliferation	Poor prognosis	^Citation63
PANDAR	Represses cell proliferation	Poor prognosis
MEG3	Promotes cell invasion and metastasis	Poor prognosis	^Citation64

Abbreviation: NSCLC, non-small cell lung cancer.

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