CT-guided cryoablation for unresectable pelvic recurrent colorectal cancer: a retrospective study

Figures & data

Table 1 Characteristics of patients at primary diagnosis and previous treatments (n=30)

Characteristics	N (%)
Age, years	57.77±10.51
Range	34–75
Sex
Male	18 (60.0)
Female	12 (40.0)
ECOG performance status
PS0	13 (43.3)
PS1	17 (56.7)
Major symptom
Perineum pain	14 (46.7)
Single lower limb numbness	7 (23.3)
Asymptomatic	9 (30.0)
Serum CEA level
Normal (<5 ng/mL)	15 (50.0)
Elevated (≥5 ng/mL)	15 (50.0)
Number of tumors	35/30
Solitary	26/26 (86.7)
Multiple	9/4 (13.3)
Tumor location
Presacral space	17/14 (48.6)
Perineum	9/9 (25.7)
Iliac region	9/7 (25.7)
Size of tumor
>5 cm	4/4 (11.4)
3–5 cm	15/14 (42.9)
≤3 cm	16/12 (45.7)
Primary tumor
Rectal cancer	29 (96.7)
Sigmoid colon cancer	1 (3.3)
T stage at primary diagnosis
1	1 (3.3)
2	7 (23.3)
3	5 (16.7)
4	17 (56.7)
Primary N stage
0	14 (46.7)
1	12 (40)
2	4 (13.3)
Primary M stage
0	22 (73.3)
1	8 (26.7)
Primary stage
I	6 (20.0)
II	6 (20.0)
III	11 (36.7)
IV	7 (23.3)
Initial surgery
Abdominoperineal resection	23 (76.7)
Low anterior resection	5 (16.7)
Transsacral local excision	2 (6.7)
Previous chemoradiotherapy
Adjuvant therapy after resection	9 (30.0)
Radiation after recurrence	8 (26.7)
Chemotherapy after recurrence	30 (100.0)

Abbreviations: CEA, carcinoembryonic antigen; ECOG, Eastern Cooperative Oncology Group.

Figure 1 Local tumor response and pain palliation efficacy.

Notes: (A) The line chart indicates the correlation between tumor size, number of antennas, tumor response, and location. (B) Kaplan–Meier curves of pain palliation after cryoablation. The median duration of pain relief was 6.0 months (95% CI: 2.67–9.33). (C) Bar graph of NRS score change and corresponding tumor size, response, and location in 21 patients with perineal or lower limb pain.

Abbreviation: NRS, Numerical Rating Scale.

Figure 2 Serum CEA analysis after cryoablation.

Notes: (A) Change in CEA in 15 patients with elevated CEA pre-cryoablation. (B) Bar graph of CEA, with tumor size and response labels for each patient.

Abbreviation: CEA, carcinoembryonic antigen.

Figure 3 Kaplan–Meier estimates of (A) OS and (B) PFS after cryoablation.

Abbreviations: PFS, progression-free survival; OS, overall survival.

Figure 4 Forest graph of results of univariate Cox regression analysis.

Abbreviations: CEA, carcinoembryonic antigen; CR, complete response; PR, partial response.

Figure 5 The survival curves of PFS by (A) tumor size, (B) sex, and (C) serum CEA after adjusting for potential confounders.

Abbreviations: CEA, carcinoembryonic antigen; PFS, progression-free survival.