Progression of the role of CRYAB in signaling pathways and cancers

Figures & data

Figure 1 Schematic representation of the structure of the CRYAB protein (including the N-terminal domain, the flexible C-terminal domain, the WDPF domain, and the α-Crystallin protein domain, and the serine (S) phosphorylation site).

Figure 2 Schematic diagram of CRYAB protein involved in the regulation of apoptosis (inhibition: ┤, activation: →).

Table 1 Expression and functional characterization of CRYAB in cancer

Name	Expression	Role	Upstream	Downstream	Reference
Breast cancer	Up-regulated	Oncogene	Ets1	Not mentioned	^Citation85
	Up-regulated	Oncogene	Not mentioned	VEGF	^Citation88
Osteosarcoma	Up-regulated	Oncogene	KLF4	Not mentioned	^Citation103
Hepatocellular carcinoma	Up-regulated	Oncogene	HSF1	Not mentioned	^Citation98
	Up-regulated	Oncogene	Not mentioned	14–3-3ζ	^Citation65
Lung cancer	Up-regulated	Oncogene	Not mentioned	Not mentioned	^Citation93
Colorectal cancer	Up-regulated	Oncogene	Not mentioned	ERK	^Citation108
Laryngeal squamous cell carcinoma	Up-regulated	Not mentioned	Not mentioned	Not mentioned	^Citation67
Oral squamous cell carcinoma	Up-regulated	Not mentioned	Not mentioned	Not mentioned	^Citation118
Nasopharyngeal carcinoma	Down-regulated	Tumor suppressor	Not mentioned	E-cadherin and β-catenin	^Citation122
Gastric cancer	Up-regulated	Oncogene	Not mentioned	NF-κB	^Citation124
Retinoblastoma	Up-regulated	Chemoresistance	Not mentioned	Not mentioned	^Citation126
Prostate cancer	Down-regulated	Tumor suppressor	MITF	Not mentioned	^Citation127
Anaplastic thyroid carcinoma	Down-regulated	Tumor suppressor	Not mentioned	Not mentioned	^Citation121
Ovarian cancer	Down-regulated	Tumor suppressor	Not mentioned	Not mentioned	^Citation132

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