Emerging roles of circular RNAs in colorectal cancer

Figures & data

Table 1 CircRNAs regulate the proliferation and progression of colorectal cancer

CircRNA	Alias	Gene symbol	Dysregulation	miRNA sponge	Target gene/pathway	Function	Reference
circACAP2	hsa_circ_0007331	ACAP2	Up	miR-21-5p	Tiam1	Proliferation(+); migration(+); invasion(+)	37
hsa_circ_0071589	–	FAT1	Up	miR-600	EZH2	Proliferation(+); migration(+); invasion(+)	39
hsa_circ_0007534	–	DDX42	Up	–	–	Proliferation(+); apoptosis(−)	44
hsa_circ_001569	hsa_circ_0000677	ABCC1	Up	miR-145	E2F5; BAG4; FMNL2;	Proliferation(+); invasion(+)	45
hsa_circ_000984	hsa_circ_0001724	CDK6	Up	miR-106b	CDK6	Proliferation(+); migration(+); invasion(+)	50
hsa_circ_0020397	–	DOCK1	up	miR-138	TERT PD-L1	proliferation(+); invasion(+); apoptosis(−)	51
circBANP	–	BANP	Up	–	p-Akt	Proliferation(+)	59
hsa_circ_0055625	–	DUSP2	Up	miR-106b-5p	ITGB8	Proliferation(+); migration(+); invasion(+);	61
hsa_circ_0000069	–	STIL	Up	–	–	Proliferation(+); migration(+); invasion(+);	62
circITCH	hsa_circ_0001141; hsa_circ_001763	ITCH	Down	–	Wnt/β-catenin signaling pathway	Proliferation(−)	24
hsa_circ_0000523	hsa_circ _006229	METTL3	Down	miR-31	Dkk1	Proliferation(−); apoptosis(+)	65
has_circ_103809	has_circ_0072088	ZFR	Down	miR-532-3P	FOXO4	Proliferation(−); migration(−)	67
circDDX17	hsa_circ_0002211	DDX17	Down	–	–	Proliferation(−); migration(−); invasion(−); apoptosis(+)	68

Table 2 CircRNAs represent potential diagnostic and prognostic biomarkers for colorectal cancer

CircRNA	Alias	Gene symbol	Dysregulation	miRNA sponge	Target gene/pathway	Biomarker	Reference
ciRS-7	CDR1as; hsa_circ_0001946	CDR1	Up	miR-7	EGFR/RAF1/MAPK pathway	Prognostic biomarker	76, 77
circHIPK3	hsa_circ_0000284	HIPK3	Up	miR-7	FAK; IGF1R; EGFR; YY1	Prognostic biomarker	85
circRNA_100290	–	SLC30A7	Up	miR-516b	FZD4	Prognostic biomarker	87
circCCDC66	has_circ_0001313	CCDC66	Up	–	–	Diagnostic biomarker; prognostic biomarker	88
hsa_circ_0136666	–	PRKDC	Up	miR‐136	SH2B1	Prognostic biomarker	89
hsa_circ_0001649	–	SHPRH	Down	–	–	Diagnostic biomarker	96
circITGA7	hsa_circ_0026782	ITGA7	Down	miR-370-3p	NF1	Diagnostic biomarker	97
hsa_circ_0000711	–	NFATC3	Down	–	–	Diagnostic biomarker; prognostic biomarker	98
hsa_circ_0014717	–	CCNB1	Down	–	p16	Prognostic biomarker	99
hsa_circ_0000567	–	SETD3	Down	–	–	Diagnostic biomarker	100
hsa_circ_001988	hsa_circ_0001451	FBXW7	Down	–	–	Diagnostic biomarker	101
hsa_circ_0026344	–	ACVRL1	Down	miR-21; miR-31	–	Prognostic biomarker	102
hsa_circ_0003906	–	–	Down	–	–	Diagnostic biomarker	103
hsa_circ_104700	–	PTK2	Down	–	–	Diagnostic biomarker	104

Figure 1 CircRNAs that can be used to predict distant metastasis and response to chemoradiotherapy. CircRNA, circular RNA;↑, upregulated;↓, downregulated.