A case of primary gastric diffuse large B-cell lymphoma occurring in chronic myeloid leukemia

Figures & data

Figure 1 FISH results: FISH (Gastric Biopsy) did not detect IGH/BCL2 (A) gene fusion, BCL6 (B) and C-MYC (C) gene fragmentation or recombination.

Figure 2 PET data: (A) PET on 2018/3/21: Abnormal increase of FDG metabolism in the irregular thickening of the gastric wall on the small curvature side of the stomach bottom malignant; (B) PET on 2018/8/14: The metabolism of FDG in gastric fundus was slightly elevated, and no specific active tumors were found.

Table 1 Reported cases of B cell NHL in patients with CML from 1999 to the present

N	Sex	Age	First author	Year	The first disease	The second disease	Interval	Involvement sites	Treatment	Px	Ref
1	M	59	Ichinohasama R	1999	CML-CP	DLBCL	33m	Lymph nodes	CAMBO-VIP+ IFN-α	Die	^Citation7
2	M	34	Adriana Zámečniková	2002	CML-CP	DLBCL	Simul	Lymph nodes and marrow	MACOP+ RT	Die	^Citation13
3	M	49	Paydas Semra	2011	CML-CP	DLBCL	14m	Jejunum	RCHOP	NC	^Citation14
4	M	60	Abuelgasim KA	2018	CML-CP	DLBCL	8m	Liver	R-EPOCH+NIL	Sur	^Citation15
5	M	63	Present study	2019	CML-CP	DLBCL	84m	Gastric	RCOP+L+NIL	Sur	^−
6	F	54	R. Salim	2002	CML-CP	CLL/SLL	36m	Bone marrow	NC	NC	^Citation17
7	M	64	Cresscenzi B	2002	CML-CP	CLL/SLL	Simul	Bone marrow	NC	NC	^Citation16
8	M	68	Mansat-De Mas V	2003	CML-CP	CLL/SLL	Simul	Bone marrow	NC	NC	^Citation18
9	F	88	Gargalloa Patricia	2005	CML-CP	CLL/SLL	20m	Bone marrow	NC	NC	^Citation19
10	M	71	Bhagavathi Sharathkumar	2008	CML-CP	CLL/SLL	84m	Bone marrow	NC	NC	^Citation20
11	M	68	GARIPIDOU VASSILIA	2005	CML-CP	PCN	22m	Bone marrow	MP+IM	NC	^Citation21
12	M	76	Galanopoulos A	2009	CML-CP	PCN	14m	Bone marrow	MP+IM	Die	^Citation22
13	F	72	Ide Masaru	2010	CML-CP	PCN	3m	Bone marrow	IM	NC	^Citation23
14	M	68	Duman Berna Bozkurt	2012	CML-CP	FL	60m	NC	NC	NC	^Citation25
15	M	73	Starr Amy G.	2018	CML-CP	FL	Simul	Lymph nodes	IM+watch	SD	^Citation24
16	M	65	Rodler Eve	2004	CML-CP	MCL	34m	Liver, pancreas	RCHOP+IM	Die	^Citation26
17	M	38	Pathak Prajwol	2017	CML-CP	MCL	Simul	No	DAS+watch	SD	^Citation27
18	F	67	Au Wing Y.	2007	CML-CP	MBCL	Simul	Mediastinal mass	ProMACE-CytaBOM+RT+Hu	PD	^Citation28
19	F	66	Takeyasu Yuki	2017	CML-CP	MBCL	2m	Mediastinal mass	RCHOP+NIL	CR	^Citation29
20	F	38	Acar Hasan	1999	CML-CP	large-cell NHL	Simul	Bone marrow	CHOP	CR	^Citation30
21	F	79	GĂMAN AMELIA MARIA	2013	CML-AP	B-cell NHL	8m	Soft palate	RT+Hu	SD	^Citation12
22	F	76	Xu Xiangdong	2014	CML-CP	MALT lymphoma	48m	orbital mass	NC	NC	^Citation31
23	F	53	Mihaylov G	2016	CML-CP	EMZBCL	84m	Left parotid	CHOP+IM	CR	^Citation32

Abbreviations: N, number; M, male; F, female; CML-CP, chronic-phase Chronic myeloid leukemia; AP, accelerated phase; FL, Follicular Lymphoma; MALT, mucosa-associated lymphoid tissue; EMZBCL, extranodal marginal zone B-cell lymphoma; MCL, Mantle Cell Lymphoma; CLL/SLL, chronic lymphocytic leukemia/small lymphocytic lymphoma; PCN, plasma cell neoplasm; MBCL, Mediastinal B cell lymphoma; m, month; Simul, Simultaneous; NC, not clear; No, The patient had no tissue or organs involved; INF-α, interferon-α; RT, radiotherapy; NIL, nilotinib; L, lenalidomide; DAS, dasatinib; IM, imatinib mesylate; Hu, hydroxyurea; Px, prognosis; Sur, survival; CR, complete remission; PD, progressive disease; SD, Stable Disease.

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