Resveratrol As A Natural Regulator Of Autophagy For Prevention And Treatment Of Cancer

Figures & data

Table 1 The Mechanisms Of Resveratrol Inducing Autophagy In Different Cancers

Cancer Type	The Mechanism Of Resveratrol Effect	Findings	References
Lung cancer	Mediate autophagocytic death through Ca2+/AMPK-mTOR signaling pathway	Inducing growth inhibition and cell death	^Citation23
Ovarian cancer	Inducing reactive ROS generation	Enhancing apoptotic and autophagic activities	^Citation25
	Inactivating STAT3 signaling, upregulating two autophagy-related genes, LC3 and Beclin-1	Increasing sensitivity to chemotherapy drugs	^Citation81
Oral cancer	Inducing autophagy and apoptosis by stimulating the expression of autophagic protein	Inducing autophagic pathway switched to the apoptotic machinery, and improving the sensitivity to cisplatin	^Citation5
Colorectal carcinomas	Inducing autophagy and initiating Caspase-8/Caspase-3-dependent apoptosis via producing ROS	Suppressing the growth of cancer cells	^Citation82
Prostate carcinomas	Activating autophagic cell death via downregulating STIM1 and mTOR pathway	Inhibiting cell proliferation and activating apoptosis	^Citation83
Breast carcinomas	Increasing PTEN protein levels and decreasing phosphorylation of AKT	Resensitizing cancer cells to treatments and inducing apoptosis and inhibiting cell proliferation	^Citation84
Head and neck cancer	Inhibiting the Nrf2/ARE pathway and facilitating p62 degradation	Reversing the resistance to ferroptosis in HNC cells	^Citation73

Figure 1 Mechanistic illustrations. Resveratrol induces autophagy by inhibiting mTOR through multiple pathways, such as promoting the association between mTOR and DEPTOR, triggering the phosphorylation of Raptor via activating AMPK and directly inhibiting mTOR, and as an SIRT1 activator to active AMPK and directly inhibit mTOR. Autophagy accelerates the degradation of p62, and then, the mTOR activation is blocked and Nrf2 activation is suppressed. As a result, resveratrol can reverse multidrug resistance in cancer cells.

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