SNHG16: A Novel Long-Non Coding RNA in Human Cancers

Figures & data

Table 1 Functional Characterization of SNHG16 in Various Cancers

Cancer Type	Expression	Numbers of Cases	Mainly Assessed Cell Lines	Related Genes	Phenotypes Affected	Role	References
Non-small cell cancer	Up	66	A549	miR-146a, MUC5AC, PCNA, MMP2, MMP9	Proliferation, migration, invasion, tumorigenesis	Oncogenic	[^Citation32]
Hepatocellular carcinoma	Up	40	HepG2, SMMC7721	miR-195	Proliferation, migration, invasion, tumorigenesis	Oncogenic	[^Citation29]
	Up	50	Hep-3B, Sk-hep-1	miR-186, ROCK1	Proliferation, migration, invasion	Oncogenic	[^Citation14]
	Up	30	HepG2	Has-miR-17-5p, p62, mTOR, NF-κB	Proliferation, migration, invasion, cell cycle, apoptosis	Oncogenic	[^Citation26]
	Up	34	Huh7, HepG2	miR-302a-3p, FGF19	Proliferation	Oncogenic	[^Citation28]
	Up	88	SMMC7721	miR-4500, STAT3, E-cadherin, N-cadherin	Proliferation, migration, invasion, EMT	Oncogenic	[^Citation27]
	Up	103	HepG2/SOR	miR-140-5p	Sorafenib resistance	Oncogenic	[^Citation25,Citation30]
Cervical cancer	Up	78	SiHa	miR-216-5p, ZEB1, E-cadherin, N-cadherin	Proliferation, migration, EMT	Oncogenic	[^Citation34,Citation35]
Osteosarcoma	Up	30	SAOS2	miR-16, ATG4B	Proliferation, migration, invasion	Oncogenic	[^Citation41]
	Up	96	U2OS, SAOS2	miR-98-5p, ZEB1, E2F5, STAT3	Proliferation, migration, invasion, cell cycle, apoptosis	Oncogenic	[^Citation38]
	Up	38	U2OS, MG-63	miR-1301, BCL-9	Proliferation, migration, invasion	Oncogenic	[^Citation40]
	Up	25	U2OS, Hfob1.19, SaOS2	miR-340, Caspase 3, caspase 7	Viability, migration, invasion, apoptosis	Oncogenic	[^Citation15]
	Up	20	MG-63, U2OS	miR-205, ZEB1, caspase3, PARP	Proliferation	Oncogenic	[^Citation39]
Papillary thyroid cancer	Up	48	IHH-4, TPC-1	miR-497, BPNA, YAP1	Proliferation, migration, invasion, apoptosis	Oncogenic	[^Citation42]
Glioma	Up	40	U251, LN229	miR-373, PI3K, AKT, EGFR, MMP2, MMP9	Proliferation, migration, invasion, apoptosis	Oncogenic	[^Citation48]
	Up	40	LN229	P21, cyclinD1, cyclinB1	Proliferation, apoptosis, cell cycle	Oncogenic	[^Citation49]
	Up	48	U251, H4	miR-4518, PRMT5, Bcl, Bax, PI3K, AKT, caspase3	Proliferation, apoptosis	Oncogenic	[^Citation50]
Colorectal cancer	Up	56	SW480, L0V0	miR-200a-3p	Proliferation, migration, invasion, tumorigenesis	Oncogenic	[^Citation45]
	Up	281	HCT116, SW480	c-Myc	Viability, apoptosis, migration	Oncogenic	[^Citation13]
Ovarian cancer	Up	103	SKOV3, H08910	AKT, PAKT, MMP9	Proliferation, migration, invasion	Oncogenic	[^Citation53]
Bladder cancer	Up	275	J82	miR-17-5p, caspase3, E-cadherin, N-cadherin, TIMP3	Viability, apoptosis, EMT, proliferation	Oncogenic	[^Citation35]
	Up	19	T24	Bcl, Bax, capase3, E-cadherin, N-cadherin, Wnt1, c-myc, P2Tkip1	Proliferation, viability, migration, invasion, apoptosis	Oncogenic	[^Citation34]
	Up	46	T24, BIU67	P21	Proliferation, migration, invasion, apoptosis, cell cycle	Oncogenic	[^Citation56]
Breast cancer	Up	30	MDA-MB-231, MCF-7	miR-98, E2F5	Migration	Oncogenic	[^Citation62]
Retinoblastoma	Up	30	SORB-50, Y-79	miR-140-5p	Proliferation, colony formation	Oncogenic	[^Citation48]
Gastric cancer	Up	54	BGC-823, SGC-7901	miR-628, NRP1	Apoptosis	Oncogenic	[^Citation68]
	Up	122	MGC-803	JAK2, p-STAT3, miR-135a	Proliferation, migration, invasion, apoptosis	Oncogenic	[^Citation66]
Pancreatic cancer	Up	46	ASPC-1	miR-218-5p, HMGB1	Migration, invasion	Oncogenic	[^Citation41]
Lymphoma	Up	48	OCL-LY7	miR-497-5p, P1M1	Proliferation, migration, invasion, apoptosis, cell cycle	Oncogenic	[^Citation50]

Table 2 Clinical Significance of SNHG16 in Diverse Cancers

Cancer Type	Overexpression of SNHG16 and Clinical Features	References
Non-small cell cancer	Tumor size, TNM stage, lymph node metastasis, shorter DFS and OS	[^Citation32]
Hepatocellular carcinoma	TNM stage, metastasis	[^Citation29]
	Tumor size, TNM stage, ALT (U/L)	[^Citation14]
	Shorter DFS and OS, multiple tumors, macro vascular invasion	[^Citation26]
	Shorter DFS and OS	[^Citation28]
	Lymph node involvement, TNM stage	[^Citation27]
	Tumor size, TNM stage, vascular invasion	[^Citation25]
	Tumor size, TNM stage, metastasis, portal vein tumor thrombus (PVTT)	[^Citation30]
Cervical cancer	Tumor size, FIGO stage, lymph node metastasis, poor differentiation	[^Citation34,Citation35]
Osteosarcoma	Tumor size, TNM stage, metastasis, shorter OS	[^Citation39]
	Tumor size, TNM stage, distance, metastasis, shorter OS	[^Citation41]
Papillary thyroid cancer	TNM stage, lymph nodes,	[^Citation42]
Glioma	Tumor size, WHO stage, shorter OS and PFS,	[^Citation51]
Colorectal cancer	Metastasis, lymph node metastasis	[^Citation13]
Ovarian cancer	Clinical stage, distance metastasis, shorter OS	[^Citation53]
Bladder cancer	Historical grade, tumor stage, lymph node metastasis	[^Citation35]
	Metastasis, lymph nodes, pathological stage	[^Citation34]
Gastric cancer	Lymph node metastasis, invasive depth, TNM stage	[^Citation67]
Pancreatic cancer	Tumor size, TNM stage, lymph node metastasis, differentiation	[^Citation41]

Figure 1 The different regulatory mechanisms of SNHG16 in different human cancers.

Abbreviations: HCC, Hepatocellular carcinoma; NSCLC, non-small cell lung cancer; OS, Osteosarcoma; GC, gastric cancer; BC, bladder cancer.

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