Recent Advances of Magnetic Nanomaterials in the Field of Oncology

Figures & data

Figure 1 Diagrams of magnetic nanoparticles (A) Magnetic nanoparticles are heated under alternating magnetic field (ACMF); (B) ACMF installation. Reprinted with permission from Yoo D,Lee JH,Shin TH,Cheon J. Theranostic magnetic nanoparticles [J]. Acc. Chem. Res. 44(10):863–874. Copyright (2011) American Chemical Society.⁴⁸ 

Table 1 Nanomagnetic Materials Used in Tumor Location and Treatment

NP Style	Cell	Effect	Mechanism	Reference
Ferrite oxide NPs (add small amounts of copper, nickel, manganese, or cobalt atoms)	Mouse cancer cell	Absorption rate of cancer increases with the particle size	Interlude magnetic field Magnetic heat therapy	^Citation20 and ^Citation23
Miniature magnetic robot	Depths of tumors or other lesions	Break through blood flow resistance	Send nanoparticles carrying drugs to the depths of tumors or other lesions	^Citation24
Microfluidic system (artificial whiplash)	Simulated vascular channel	External magnetic field	Combining the size of 200 Nanopolystyrene particles are pushed into the target tissue at almost twice the depth of the immersion tissue	^Citation3
Magnetic bacteria	Target tumors	The bacteria, which produce iron oxide, rotating magnetic field is applied to a specific direction	Can quickly push nanoparticles to the target tissue	^Citation18
Magnetic iron oxide nanoparticles, magnetic nanoclusters, folic acid molecules	Mouse cancer cell	Cross-change magnetic induction heat therapy	The growth of tumors in mice was obviously inhibited.	^Citation17
PEG-based magnetic nanoparticles	Surface of the mouse tumor	Heat ablation	Tumor to subside	^Citation47
Fusion magnetic manganese-zinc ferrite nanocrystals	Mouse cancer cell	Heat therapy	Effectively inhibiting the growth of the tumor	^Citation13
PSA-ACT,	PSA antibody	PSA-ACT, graphene field-effect transistor biosensor	PSA-ACT can be captured by PSA antibody.	^Citation21
Nanoparticles, NPs, graphene, rGO-NPs	PSA-ACT in the serum sample	Increase the surface area ratio	Improve the sensitivity of the sensor	^Citation8
Platinum particles, HER3 genetically engineered scFv, tumor marker HER3	Tumor marker HER3	Single-chain antibodies	Solve the Debye length problem of the sensor	^Citation9
Polymethyl methacry- late, carboxylated multi-walled carbon nanotubes/reduced graphene oxide	Early detection of tumors	Construct field-effect transistors; and CA125 aptamers were modified as capture probes on the conductive channel.	G-FET biosensors have such good sensitivity and specificity.	^Citation16
Few-layer graphene, PPy-NDFLG	VEGF expression	N-doped graphene, PPy-NDFLG by using polypyrrole as an N source and a chemical vapor deposition production	Enhance the affinity of the capture probe	^Citation27

Figure 2 Map of the nanomaterial field-effect transistor (A) Structure of the nanomaterial field-effect transistor; (B) The Change of the function of the nanomaterial field-effect transistor before and after detection. Reprinted with permission from Stine R,Mulvaney SP,Robinson JT,Tamanaha CR,Sheehan PE. Fabrication, optimization, and use of graphene field effect sensors[J]. Anal Chem. 85(2):509–521. Copyright (2013) American Chemical Society.⁴⁹

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