Figures & data
Table 1 Clinical Features of Patients with HCC and the Controls
Figure 1 Boxplots of serum VEGF and MMP-9 in healthy controls, EGFR-negative patients, and EGFR-positive patients. (A) Serum VEGF concentration in three different groups. (B) Serum MMP-9 concentration in three different groups. Fold change and P-values are listed in the order of control vs EGFR-positive patients, and EGFR-negative patients vs EGFR-positive patients.
![Figure 1 Boxplots of serum VEGF and MMP-9 in healthy controls, EGFR-negative patients, and EGFR-positive patients. (A) Serum VEGF concentration in three different groups. (B) Serum MMP-9 concentration in three different groups. Fold change and P-values are listed in the order of control vs EGFR-positive patients, and EGFR-negative patients vs EGFR-positive patients.](/cms/asset/0bef3056-6712-44b1-b1f1-1e88c30d51fa/dott_a_12175299_f0001_b.jpg)
Table 2 Relation of Serum VEGF and MMP9 to Clinicopathological Characteristics of 139 Patients with HCC (Concentration Unit: VEGF, Pg/mL; MMP-9, Ng/mL)
Figure 2 Changes in serum VEGF and MMP-9 levels in patients with HCC after TACE therapy. Mean changes in serum (A) VEGF and (B) MMP-9 levels between recurrent and non-recurrent patients after TACE therapy. Mean changes in serum (C) VEGF and (D) MMP-9 levels between EGFR-negative and -positive patients after TACE therapy. Mean changes in serum (E) VEGF and (F) MMP-9 levels in patients with HCC after TACE therapy with different chemotherapeutic drugs relative to the pre-treatment value.
![Figure 2 Changes in serum VEGF and MMP-9 levels in patients with HCC after TACE therapy. Mean changes in serum (A) VEGF and (B) MMP-9 levels between recurrent and non-recurrent patients after TACE therapy. Mean changes in serum (C) VEGF and (D) MMP-9 levels between EGFR-negative and -positive patients after TACE therapy. Mean changes in serum (E) VEGF and (F) MMP-9 levels in patients with HCC after TACE therapy with different chemotherapeutic drugs relative to the pre-treatment value.](/cms/asset/92f55d7f-35c6-4e2d-9e62-1362d25f6626/dott_a_12175299_f0002_c.jpg)
Figure 3 Boxplots of serum (A) VEGF and (B) MMP-9 levels in EGFR-negative and -positive patients after TACE therapy with chemotherapeutic drugs based on adriamycin and its isomers.
![Figure 3 Boxplots of serum (A) VEGF and (B) MMP-9 levels in EGFR-negative and -positive patients after TACE therapy with chemotherapeutic drugs based on adriamycin and its isomers.](/cms/asset/532c1ee5-b8b9-4c8e-8e99-57d9b51f51ae/dott_a_12175299_f0003_b.jpg)
Figure 4 Boxplots of serum (A) VEGF and (B) MMP-9 levels in EGFR-negative and -positive patients after TACE therapy with chemotherapeutic drugs based on platinum.
![Figure 4 Boxplots of serum (A) VEGF and (B) MMP-9 levels in EGFR-negative and -positive patients after TACE therapy with chemotherapeutic drugs based on platinum.](/cms/asset/b992eb22-6c20-4fed-b27f-41e1987362b7/dott_a_12175299_f0004_b.jpg)
Figure 5 Boxplots of serum (A) VEGF and (B) MMP-9 levels in EGFR-negative and -positive patients after TACE therapy with chemotherapeutic drugs based on other drugs.
![Figure 5 Boxplots of serum (A) VEGF and (B) MMP-9 levels in EGFR-negative and -positive patients after TACE therapy with chemotherapeutic drugs based on other drugs.](/cms/asset/e77f6a7f-6d30-431f-acab-1eca4e876fc1/dott_a_12175299_f0005_b.jpg)
Figure 6 Longitudinal serum (A) VEGF and (B) MMP-9 in individual patients. Serum concentrations of VEGF and MMP-9 were plotted on the Y-axis and sampling time after therapy were plotted on the X-axis. Each dot represents a sample and different time points for the same patient is linked by a line.
![Figure 6 Longitudinal serum (A) VEGF and (B) MMP-9 in individual patients. Serum concentrations of VEGF and MMP-9 were plotted on the Y-axis and sampling time after therapy were plotted on the X-axis. Each dot represents a sample and different time points for the same patient is linked by a line.](/cms/asset/63dd24d3-0c48-4f51-a818-bb7cc21c4d00/dott_a_12175299_f0006_c.jpg)