https://orcid.org/0000-0002-2981-4740
Figures & data
Figure 1 The flowchart of the study design.
Table 1 Baseline Clinical Characteristics of the NSCLC Patients (N = 300)
Table 2 A Comprehensive View of the EGFR Mutations
Table 3 The Characteristics of the Patients with Uncommon EGFR and de novo T790M Mutations
Figure 2 (A) Non-specific signals of FAM were shown for the NSCLC cell lines with wild type EGFR. (B, C, D) Three clinical pretreatment NSCLC patients with concomitant de novo T790M and L858R mutations in which a ddPCR method was performed to detect the allelic relation between the two mutations, double-positive signals for the de novo T790M (FAM labeled) and L858R of EGFR (VIC labeled) were shown in the B, C and D. For the ddPCR results, the FAM and VIC negative signals were indicated as black color. The signals of wild-type EGFR L858R and wild-type T790M mutations were depicted as blue color. The signals of EGFR L858R mutation positive were depicted as green color. Double positive signals for the de novo T790M with in cis L858R mutation were depicted as orange color.
Figure 3 The de novo T790M mutant abundance in the FFPE tumor tissues samples and FFPE adjacent normal lung samples.
