Biological Function of HYOU1 in Tumors and Other Diseases

Figures & data

Table 1 Specific Cancers and Their Association with HYOU1

Cancer Type	Expression	Function	Reference
Epithelial ovarian cancer	Upregulated	Promoting proliferation, invasion and migration	[^Citation34]
Breast cancer	Upregulated	Reducing apoptosis	[^Citation43]
Thyroid cancer	Upregulated	Reducing apoptosis	[^Citation45,Citation52]
Gastric cancer	Upregulated	Reducing apoptosis	[^Citation46]
Bladder cancer	Upregulated	Promoting invasion	[^Citation42]
Kaposi’s sarcoma	Upregulated	Promoting migration and survival	[^Citation40]
Prostate cancer	Upregulated	Promoting angiogenesis and tumorigenicity	[^Citation44]
Nasopharyngeal carcinoma	Upregulated	Associating with shorter progression-free survival and overall survival	[^Citation41]
Non-small cell lung cancer	Upregulated	Promoting invasion, reducing apoptosis, chemoresistance	[^Citation49]

Figure 1 The role model of intracellular HYOU1 in tumor development. The endoplasmic reticulum stress response up-regulates the expression of HYOU1 through the PERK-eIF2α-ATF4 pathway and the active form of the p50-ATF6 pathway, and inhibit the expression of CHOP and reduce apoptosis. HYOU1 promotes tumor angiogenesis by promoting VEGF secretion. HYOU1 promotes cell proliferation, invasion and migration by up-regulating the expression of p-PI3K and p-Akt. HYOU1 reduces apoptosis by down-regulating the expression of IFN-α and IFN-β.

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