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OncoTargets and Therapy Volume 14, 2021 - Issue
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Case Report

Promising Response to Lenalidomide-Combination Therapy in a Discordant Lymphoma Consisting of EBV-Positive Diffuse Large B-Cell Lymphoma and Angioimmunoblastic T-Cell Lymphoma: A Case Report

Pan Hu1 Department of Oncology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, 226001, People’s Republic of ChinaView further author information
,
Yu Ben1 Department of Oncology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, 226001, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0003-4527-9845View further author information
ORCID Icon,
Juan Liu1 Department of Oncology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, 226001, People’s Republic of ChinaView further author information
,
Weicheng Zheng1 Department of Oncology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, 226001, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0002-0405-2559View further author information
ORCID Icon,
Xiyue Yan1 Department of Oncology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, 226001, People’s Republic of ChinaView further author information
,
Yaping Zhang2 Department of Hematology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, 226001, People’s Republic of ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-3381-1486View further author information
ORCID Icon &
Wenyu Shi1 Department of Oncology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, 226001, People’s Republic of China;2 Department of Hematology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, 226001, People’s Republic of ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0002-2371-3332View further author information
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Pages 2489-2495 | Published online: 12 Apr 2021

Figures & data

Figure 1 Immunohistochemical staining of angioimmunoblastic T-cell lymphoma tissue sample. Immunohistochemical staining of H&E (A) and Ki67 (I), negative for CD20 (B) and positive for CD3 (C), CD21 (D), CD10 (E), Bcl-6 (F), CD4 (G), PD-1 (H) (A: H&E×100, inset: H&E×400, B–I: ×200).

Figure 1 Immunohistochemical staining of angioimmunoblastic T-cell lymphoma tissue sample. Immunohistochemical staining of H&E (A) and Ki67 (I), negative for CD20 (B) and positive for CD3 (C), CD21 (D), CD10 (E), Bcl-6 (F), CD4 (G), PD-1 (H) (A: H&E×100, inset: H&E×400, B–I: ×200).

Figure 2 Immunohistochemical staining of diffuse large B-cell lymphoma tissue sample. Immunohistochemical staining of H&E (A) and Ki67 (I), positive for CD20 (B), MUM1 (D), CD10 (E), Bcl-6 (F), EBER (G) and negative for CD3 (C), PD-1 (H) (A: H&E×100, inset: H&E×400, B–H: ×200, I: ×100).

Figure 2 Immunohistochemical staining of diffuse large B-cell lymphoma tissue sample. Immunohistochemical staining of H&E (A) and Ki67 (I), positive for CD20 (B), MUM1 (D), CD10 (E), Bcl-6 (F), EBER (G) and negative for CD3 (C), PD-1 (H) (A: H&E×100, inset: H&E×400, B–H: ×200, I: ×100).

Figure 3 Comparison of positron emission tomography/computed tomography scans before and after lenalidomide-combination treatment.

Figure 3 Comparison of positron emission tomography/computed tomography scans before and after lenalidomide-combination treatment.

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