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Case Report

Complete Pathologic Response After Concurrent Treatment with Pembrolizumab and Radiotherapy in Metastatic Colorectal Cancer: A Case Report

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Pages 2555-2561 | Published online: 13 Apr 2021

Figures & data

Figure 1 (A) The pathological findings of colonoscopy biopsy. It shows that atypical cells are arranged in an irregular glandular tube-like arrangement, with large and deeply stained nuclei and obvious mitosis (H&E, 40x). (B) The microscopic findings of the resected specimen. There is only mucus but no exact cancer cells were found (H&E, 40x).

Figure 1 (A) The pathological findings of colonoscopy biopsy. It shows that atypical cells are arranged in an irregular glandular tube-like arrangement, with large and deeply stained nuclei and obvious mitosis (H&E, 40x). (B) The microscopic findings of the resected specimen. There is only mucus but no exact cancer cells were found (H&E, 40x).

Figure 2 The intestinal and kidney mass treatment effect images of patient at baseline, after pembrolizumab and after surgery, respectively. The red arrow indicates the lesion.

Figure 2 The intestinal and kidney mass treatment effect images of patient at baseline, after pembrolizumab and after surgery, respectively. The red arrow indicates the lesion.

Figure 3 Immunohistochemical staining for MLH1, MSH2, MSH6, and PMS2 on the intestinal biopsy samples reveal loss of MLH1 and PMS2 protein expression (40x).

Figure 3 Immunohistochemical staining for MLH1, MSH2, MSH6, and PMS2 on the intestinal biopsy samples reveal loss of MLH1 and PMS2 protein expression (40x).

Figure 4 The irradiated gross tumor volume and the radiation dose plan.

Figure 4 The irradiated gross tumor volume and the radiation dose plan.

Figure 5 Dynamic change curves of CEA in peripheral blood during the whole treatment process.

Abbreviation: CEA, carcinoembryonic antigen.
Figure 5 Dynamic change curves of CEA in peripheral blood during the whole treatment process.

Figure 6 Resection samples of intestines and kidneys.

Figure 6 Resection samples of intestines and kidneys.