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OncoTargets and Therapy Volume 14, 2021 - Issue
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Review

Immune Regulation of the cGAS-STING Signaling Pathway in the Tumor Microenvironment and Its Clinical Application

Feifei Pu1 Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0002-9174-8780
ORCID Icon,
Fengxia Chen2 Department of Radiation and Medical Oncology, Zhongnan Hospital, Wuhan University, Wuhan, People’s Republic of China
,
Jianxiang Liu1 Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China
,
Zhicai Zhang1 Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China
&
Zengwu Shao1 Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of ChinaCorrespondence[email protected]
Pages 1501-1516 | Published online: 01 Mar 2021

Figures & data

Figure 1 The cGAS-STING signaling pathway. Exogenous and endogenous DNA activate cGAS to generate second messenger 2ʹ,3ʹ-cGAMP. After 2ʹ,3ʹ-cGAMP binds to the downstream receptor protein STING, STING transfers to golgi body and polymerization occurs, and then, TBK1, IRF3 and NF-κB were recruited. This promotes the phosphorylation of IRF3 and NF-κB and facilitates their entry into the nucleus, finally, the transcription of genes associated with inflammatory factors is activated.

Figure 1 The cGAS-STING signaling pathway. Exogenous and endogenous DNA activate cGAS to generate second messenger 2ʹ,3ʹ-cGAMP. After 2ʹ,3ʹ-cGAMP binds to the downstream receptor protein STING, STING transfers to golgi body and polymerization occurs, and then, TBK1, IRF3 and NF-κB were recruited. This promotes the phosphorylation of IRF3 and NF-κB and facilitates their entry into the nucleus, finally, the transcription of genes associated with inflammatory factors is activated.

Table 1 Clinical Trials of STING Agonists

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