Intravascular Papillary Endothelial Hyperplasia Mimicking Vaginal Malignant Tumor in a Post-Radiotherapy Patient: A Case Report and Literature Review

Figures & data

Figure 1 Colposcopes view of the lesion. (A) An 8-millimeter-diameter intravascular papillary endothelial hyperplasia in the right apical angle of the vagina with medium amount of blood. The lesion is red to purple coloration, and a medium amount of blood was seen. (B) Iodine staining of the lesion.

Figure 2 Pathology and immunohistochemistry result (200×). (A) Microscopic finding presents proliferation of erythrocytes within a dilated vascular structure. (B) Ki-67 labeling index was about 5%. Immunohistochemistry shows the tissue was positive for CD31 (C) and CD34 (D).

Table 1 Summary of Reports of Masson’s Tumor Occurred in the Female Reproductive System

Reference	Age (Years)	Region	Symptom	Size	Treatment
Kim et al (2014)^Citation19	37	Vulva	A palpable mass with intermittent vulvar pain	30x20mm	Excision
Beutler et al (2016)^Citation4	32	Vulva	Painless, black papule	3×2mm	Excisional biopsy
Nwokolo et al (2020)^Citation20	35	Vulva	Tender mass with worsening pain	20x30mm	Excision
Sherring et al (2020)^Citation21	44	Left ovary	Intermittent pelvic discomfort	200×180×95mm	Hysterectomy, bilateral salpingo-oophorectomy, and omentectomy
Sherring et al (2020)^Citation21	57	Left ovary	Increasing abdominal girth	260×225×165mm	Hysterectomy, bilateral salpingo-oophorectomy, and omentectomy
Susini et al (2010)^Citation10	40	Uterine cervix	Severe pain and vaginal bleeding	70mm	Excision

Abbreviations: IPEH, intravascular papillary endothelial hyperplasia; HPV, human papillomavirus; NS, not state; HHV, human herpesvirus.

Kim T-H, Lee -H-H, Koh E-S. Intravascular papillary endothelial hyperplasia (masson’s tumour) in the vulva. Eur J Obstet Gynecol Reprod Biol. 2013;169(2):413–414. doi:10.1016/j.ejogrb.2013.03.034

 PubMed Web of Science ®Google Scholar

Beutler BD, Cohen PR. Intravascular papillary endothelial hyperplasia of the vulva: report of a patient with masson tumor of the vulva and literature review. Dermatol Online J. 2016;22(5):13030. doi:10.5070/D3225030943

 Google Scholar

Nwokolo V, Veeramachaneni R, Rivas SD. Vulvar intravascular papillary endothelial hyperplasia or masson’s tumor: a case report. Case Rep Womens Health. 2020;28:e00250. doi:10.1016/j.crwh.2020.e00250

 PubMedGoogle Scholar

Sherring K, Foot O, Barton DP, et al. Ovarian extravascular papillary endothelial hyperplasia (masson tumor) mimicking a primary gynecologic malignancy. Int J Gynecol Pathol. 2020.

 Web of Science ®Google Scholar

Susini T, Molino C, Castiglione F, et al. Masson’s vegetant hemangioendothelioma arising in the uterine cervix during pregnancy: a case report. J Womens Health. 2010;19(9):1759–1762. doi:10.1089/jwh.2010.1979

 Web of Science ®Google Scholar