The Emerging Role of Circ-SHPRH in Cancer

Figures & data

Figure 1 Schematic diagram depicting circ-SHPRH formation.

Figure 2 MicroRNAs that can be sponged by circ-SHPRH or genes and proteins associated with circ-SHPRH, according to published reports on human cancer. Trapezium represents microRNAs that can be sponged by circ-SHPRH.Square represents genes and proteins associated with circ-SHPRH.

Table 1 Clinicopathological Parameters of Circ-SHPRH in Human Tumors

Cancer Types	Samples Size (Normal:Tumor)	Expression	Clinicopathologic Features	Clinical Importance	References
HCC	(89:89)	Downregulated	Tumor size and tumor embolus	Diagnosis Biomarker	[^Citation42]
HCC	(77:77)	Downregulated	Overall Surxixal	Prognostic Biomarker	[^Citation54]
HCC	(84:84)	Downregulated	Grade of differentiation and tumor satellite	–	[^Citation55]
GC	(76:76)	Downregulated	Pathological differentiation	Diagnosis Biomarker	[^Citation69]
NSCLC	(53:53)	Downregulated	TNM stage and lymph nodes	Prognostic Biomarker	[^Citation43]
CRC	(64:64)	Downregulated	Pathological differentiation	Diagnosis Biomarker	[^Citation41]
CCA	(76:76)	Downregulated	Tumor size and differentiation grade	–	[^Citation84]
PDAC	(58:58)	Downregulated	Tumor stage and grade of differentiation Overall Surxixal	Prognostic Biomarker	[^Citation87]
RB	(6:60)	Downregulated	Tumor size and IIRC stage Overall Surxixal	Prognostic Biomarker	[^Citation91]
GBM	(64:64)	Downregulated	Tumor size and WHO grade	Prognostic Biomarker	[^Citation97]

Table 2 Functional Characteristics of Circ-SHPRH in Multiple Human Cancers

Cancer Types	Expression	Roles	Functional Roles	Target miRNA	Related Genes and Protein	Signal Pathway	Study Model	References
HCC	Downregulated	Tumor suppressor	Migration	–	MMP9,MMP10, MMP13	–	vitro	[^Citation42]
HCC	Downregulated	Tumor suppressor	Viability,Proliferation, Migration,Invasiion,Apoptosis	–		–	vitro	[^Citation54]
HCC	Downregulated	Tumor suppressor	Viability,Proliferation, Migration	MiR-127-5p, MiR-612,MiR-4688	SHPRH,ZEB-1 E-cadherin,N-cadherin	-	vivo/vitro	[^Citation55]
GC	Downregulated	Tumor suppressor	Viability,Proliferation, Migration,Invasiion,Apoptosis	MiR-20a	Wnt3a,β-catenin,ERK	ERK Wnt/β-catenin	vitro	[^Citation45]
NSCLC	Downregulated	Tumor suppressor	Viability,Proliferation, Migration,Invasiion	MiR331-3p, MiR-8-5p	-	-	vivo/vitro	[^Citation43]
OS	Downregulated	Tumor suppressor	Viability,Apoptosis,	MiR-338-5p, MiR-647,MiR-942	CDK4,CDK6 Apaf-1,Caspase-3,Caspase-9 STAT3,STAT5	STAT	vitro	[^Citation75]
CCA	Downregulated	Tumor suppressor	Viability,Migration, Invasiion,Apoptosis	-	MMP-9	-	Vivo/vitro	[^Citation84]
PDAC	Downregulated	Tumor suppressor	Viability,Proliferation, Apoptosis	-	Caspase-3,Caspase-9	-	vitro	[^Citation87]
RB	Downregulated	Tumor suppressor	Viability,Proliferation, Apoptosis	-	Caspase-3,Caspase-9 Bcl-2, Bax P-Akt,P-mTOR	Akt /mTOR	Vivo/vitro	[^Citation91]
GBM	Downregulated	Tumor suppressor	Proliferation,Apoptosis	-	Caspase-3,Caspase-9 Bcl-2, Bax	-	Vivo/vitro	[^Citation97]

Qin M, Liu G, Huo X, et al. Hsa_circ_0001649: a circular RNA and potential novel biomarker for hepatocellular carcinoma. Cancer Biomarkers. 2016;16(1):161–169.

 PubMed Web of Science ®Google Scholar

Zhang X, Qiu S, Luo P, et al. Down-regulation of hsa_circ_0001649 in hepatocellular carcinoma predicts a poor prognosis. Cancer Biomarkers. 2018;22(1):135–142.

 PubMed Web of Science ®Google Scholar

Su Y, Xu C, Liu Y, et al. Circular RNA hsa_circ_0001649 inhibits hepatocellular carcinoma progression via multiple miRNAs sponge. Aging. 2019;11(10):3362–3375.

 PubMedGoogle Scholar

Li WH, Song YC, Zhang H, et al. Decreased expression of Hsa_circ_00001649 in gastric cancer and its clinical significance. Dis Markers. 2017;4587698.

 PubMed Web of Science ®Google Scholar

Liu T, Song Z, Gai Y. Circular RNA circ_0001649 acts as a prognostic biomarker and inhibits NSCLC progression via sponging miR-331-3p and miR-338-5p. Biochem Biophys Res Commun. 2018;503(3):1503–1509.

 PubMed Web of Science ®Google Scholar

Ji W, Qiu C, Wang M, et al. Hsa_circ_0001649: a circular RNA and potential novel biomarker for colorectal cancer. Biochem Biophys Res Commun. 2018;497(1):122126.

 Web of Science ®Google Scholar

Xu Y, Yao Y, Zhong X, et al. Downregulated circular RNA hsa_circ_0001649 regulates proliferation, migration and invasion in cholangiocarcinoma cells. Biochem Biophys Res Commun. 2018;496(2):455–461.

 PubMed Web of Science ®Google Scholar

Jiang Y, Wang T, Yan L, et al. A novel prognostic biomarker for pancreatic ductal adenocarcinoma: hsa_circ_0001649. Gene. 2018;675:88–93.

 PubMed Web of Science ®Google Scholar

Xing L, Zhang L, Feng Y, et al. Downregulation of circular RNA hsa_circ_0001649 indicates poor prognosis for retinoblastoma and regulates cell proliferation and apoptosis via AKT/mTOR signaling pathway. Biomedicine Pharmacother. 2018;105:326–333.

 PubMed Web of Science ®Google Scholar

Wang Y, Sui X, Zhao H, et al. Decreased circular RNA hsa_circ_0001649 predicts unfavorable prognosis in glioma and exerts oncogenic properties in vitro and in vivo. Gene. 2018;676:117–122.

 PubMed Web of Science ®Google Scholar

Sun H, Wang Q, Yuan G, et al. Hsa_circ_0001649 restrains gastric carcinoma growth and metastasis by downregulation of miR-20a. J Clin Lab Anal. 2020;34:(6)e23235.

 Web of Science ®Google Scholar

Sun D, Zhu D. Circular RNA hsa_circ_0001649 suppresses the growth of osteosarcoma cells via sponging multiple miRNAs. Cell Cycle. 2020;19(20):2631–2643.

 PubMed Web of Science ®Google Scholar