Role of integrin-linked kinase in drug resistance of lung cancer

Figures & data

Figure 1 Survival rates of A549/GemR and A549 cell lines.

Abbreviations: GemR, gemcitabine resistant; IC₅₀, half maximal inhibitory concentration.

Figure 2 The relative expression of ILK in A549/GemR and A549 cells.

Notes: (A) The messenger RNA expression of ILK. (B) The protein expression of ILK.
Abbreviations: ILK, integrin-linked kinase; GemR, gemcitabine resistant.

Figure 3 The function of ILK in gemcitabine resistance.

Notes: (A) The expression of ILK in A549/GemR shILK cells. (B) The survival rate of A549/GemR shILK cells.
Abbreviations: ILK, integrin-linked kinase; GemR, gemcitabine resistant; ILK, integrin-linked kinase.

Figure 4 The molecular mechanism of ILK in gemcitabine-resistant lung cancer.

Notes: (A) The markers of EMT were detected by Western blot. (B) The expression of MRP1 was detected by Western blot.
Abbreviations: ILK, integrin-linked kinase; EMT, epithelial–mesenchymal transition; MRP1, multidrug resistant protein 1; FN, fibronectin; GemR, gemcitabine resistant.