Sudden bilateral hearing loss in gastric cancer as the only symptom of disease

Figures & data

Figure 1 Brain axial magnetic resonance imaging T1-weighted sequence after gadolinium intravenous administration showing thickening and enhancement of bilateral vestibulocochlear nerves and solitary lesion in right cerebellar hemisphere.

Figure 2 Entire stomach wall infiltrated with solid nests of tumor tissue, with occasional central necrosis. Tumor is adenocarcinoma grade III.

Notes: Hematoxylin and eosin stain; ×200 magnification.

Table 1 Bilateral hearing loss as presenting symptom of gastric cancer

Study	Cases, n	Sex, M/F	Age, years	Symptom(s)	Diagnosis method(s)	Metastatic site(s)	Treatment	Survival, months
Ohno et al 2010^Citation16	1	M	62	Bilateral HL	MRI brain, EGD	Lymph nodes, brain, spinal meninges	S-1, paclitaxel RT	3.0
Okamoto et al 2007^Citation17	1	M	63	Bilateral HL	MRI, autopsy	Meninges	–	2.5
Schneider et al 2009^Citation18	1	M	Middle-aged	Bilateral HL	MRI, EGD, autopsy	Bone marrow, pancreatic, meninges	–	3.0
Cserni et al 2007^Citation19	1	M	62	Bilateral HL, headache, vomiting	CSF, autopsy	Widely metastasized	–	1.0
Miura et al 2006^Citation20	1	M	70	Dizziness, headache, HL	CSF, EGD	Meninges	S-1, MTX intrathecal	12.0

Abbreviations: CSF, cerebrospinal fluid; EGD, esophagogastroduodenoscopy; HL, hearing loss; M, male; MRI, mag netic resonance imaging; MTX, methotrexate; RT, radiotherapy; S-1, oral fluoropyrimidine.

Table 2 Threshold cycle values by quantitative real-time polymerase chain reaction

Sample	CT values
	GAPDH	DFNA5
GC	28.02±0.77	ND (>40)
BM	27.36±0.85	ND (>40)
HST	25.65±1.34	33.56±2.38

Abbreviations: BM, brain metastasis; C_T, threshold cycle; GAPDH, glyceraldehyde 3-phosphate dehydrogenase; GC, gastric cancer; HST, healthy stomach tissue; ND, not determined. Values are expressed as averages ± SD and are derived from three isolations.

OhnoTYokoyamaYAiharaRSudden bilateral sensorineural hearing loss as the presenting symptom of meningeal carcinomatosis of gastric cancer: report of a caseSurg Today201040656156520496139

 PubMed Web of Science ®Google Scholar

OkamotoYSugiyamaHYamamotoTA case of meningeal car-cinomatosis presenting with bilateral hearing lossBrain Nerve200759121385138918095490

 PubMedGoogle Scholar

SchneiderSKrikmannULüüsSMKullaAHaldreSNeoplastic meningitis as the presenting manifestation of gastric adenocarcinomaBMJ Case Rep20092009 pii: bcr07.2008.056510.1136/bcr.07.2008.0565

 Google Scholar

CserniGVágóTTörökNCarcinomatous meningitisLege Artis Med2007171068869319227599

 PubMedGoogle Scholar

MiuraMIijimaNHayashidaKCase of leptomeningeal carci-nomatosis effectively treated with intrathecal chemotherapy using ven-triculoperitoneal shuntRinsho Shinkeigaku200646640440916986702

 PubMedGoogle Scholar