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Original Research

DDMC-p53 gene therapy with or without cisplatin and microwave ablation

, , , , , , , , , , , & show all
Pages 1165-1173 | Published online: 20 May 2015

Figures & data

Figure 1 Injection used to apply Lewis lung carcinoma cells.

Figure 1 Injection used to apply Lewis lung carcinoma cells.

Figure 2 Vial containing the non-viral DDMC vector.

Figure 2 Vial containing the non-viral DDMC vector.

Figure 3 Molecular structure of the non-viral vector DDMC.

Abbreviation: DDMC-p53, 2-diethylaminoethyl-dextran methyl methacrylate copolymer with p53.
Figure 3 Molecular structure of the non-viral vector DDMC.

Figure 4 Microwave ablation generator manufactured by Valleylab, a division of Tyco Healthcare Group LP (Boulder, CO, USA) and kindly provided by Joshua Stopek.

Figure 4 Microwave ablation generator manufactured by Valleylab, a division of Tyco Healthcare Group LP (Boulder, CO, USA) and kindly provided by Joshua Stopek.

Figure 5 BALBC mouse with tumor.

Figure 5 BALBC mouse with tumor.

Figure 6 DDMC with p53.

Notes: Blue arrows indicate the DDMC-p53 complex within the tissue. Magnification 100×.
Abbreviation: DDMC, 2-diethylaminoethyl-dextran methyl methacrylate copolymer.
Figure 6 DDMC with p53.

Figure 7 Control group (without therapy).

Note: Magnification 100×.
Figure 7 Control group (without therapy).

Figure 8 DDMC with p53 plus microwave group.

Note: Magnification 100×.
Abbreviation: DDMC, 2-diethylaminoethyl-dextran methyl methacrylate copolymer.
Figure 8 DDMC with p53 plus microwave group.

Figure 9 DDMC-p53 complex plus cisplatin.

Note: Magnification 40×.
Abbreviation: DDMC, 2-diethylaminoethyl-dextran methyl methacrylate copolymer.
Figure 9 DDMC-p53 complex plus cisplatin.

Figure 10 Cisplatin group.

Note: Magnification 100×.
Figure 10 Cisplatin group.

Figure 11 Microwave group.

Note: Magnification 100×.
Figure 11 Microwave group.

Figure 12 DDMC-p53 plus cisplatin plus microwave group.

Notes: Magnification 100×. The blue arrows indicate the DDMC-p53 complex within the tissue.
Abbreviation: DDMC, 2-diethylaminoethyl-dextran methyl methacrylate copolymer.
Figure 12 DDMC-p53 plus cisplatin plus microwave group.