A study on the effect of IL-6 gene polymorphism on the prognosis of non-small-cell lung cancer

Figures & data

Figure 1 Image of agarose gel fragments of genotypes.

Table 1 Basic data of patients (434 cases)

Characteristics	N	Percentage
Sex
Male	339	78.11
Female	93	21.43
No information	2	0.46
Age, years (mean ± standard deviation)	63.00±10.25
Histology
Epidermoid carcinoma	165	38.02
Adenocarcinoma	207	47.70
Undifferentiated carcinoma	40	9.22
Large-cell carcinoma	14	3.22
Mixed-type carcinoma	5	1.15
No information	3	0.69
Tumor stage
Stage I	46	10.60
Stage II	31	7.14
Stage III	192	44.24
Stage IV	162	37.33
No information	3	0.69
Smoking history
Smoker	313	72.12
Nonsmoker	114	26.27
No information	7	1.61
Cancer pain quantification
Global Pain Score <5	189	43.5
Global Pain Score ≥5	245	56.5

Figure 2 Overall survival analysis of patients.

Notes: The overall survival rate and distribution were analyzed using the Kaplan–Meier curve. Kaplan–Meier survival curves and logrank test were used to determine the P-value.

Table 2 Multivariate Cox regression analysis of the overall survival rate prediction factors

	Hazard ratio	95% credibility interval	P-value
IL-6 −174G/C	1.682	1.077–2.628	0.022
Sex	0.964	0.668–1.391	0.844
Age (≥63 years, <63 years)	0.982	0.788–1.224	0.871
Smoking history	1.423	1.001–2.024	0.049
Histology	0.933	0.810–1.074	0.336
Tumor stage	2.470	1.969–3.099	<0.001

Table 3 Correlations between IL-6 −174G/C gene polymorphisms and the degree of pain or MEDD

Genotype	Pain degree			MEDD
	Total, mean (SD)	Males, mean (SD)	Females, mean (SD)	Total, mean (SD)	Males, mean (SD)	Females, mean (SD)
IL-6 −174G/C
GG	5.00 (3.20)	4.68 (3.21)	5.40 (3.21)	69.61 (77.4)	72.89 (83.92)	64.81 (68.06)
GC	4.30 (2.81)	5.43 (3.18)	3.47 (2.24)	73.17 (93.6)	75.56 (117.90)	71.30 (71.97)
CC	3.42 (1.86)	3.67 (2.5)	3.40 (0.894)	181.67 (228.0)	235.71 (107.39)	106.00 (98.38)
GC + CC	4.11 (2.98)	4.9 (3.04)	3.46 (2.02)	97.7 (140.0)	120.40 (188.19)	77.5 (76.40)
Odds ratio (95% CI)	1.5 (1.2–1.9)	1.3 (1.1–1.7)	1.7 (1.4–2.4)	1.2 (0.9–1.6)	1.1 (0.8–1.5)	1.4 (1.1–2.5)
P	0.067	0.053	0.075	0.004	0.0023	0.0055

Abbreviations: CI, credibility interval; MEDD, morphine equivalent daily dose; SD, standard deviation.