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Original Research

The Single Nucleotide Polymorphisms of AP1S1 are Associated with Risk of Esophageal Squamous Cell Carcinoma in Chinese Population

Feng Su1 Department of Thoracic Surgery, Zhongshan Hospital of Fudan University, Shanghai, People’s Republic of China

Yong Fang1 Department of Thoracic Surgery, Zhongshan Hospital of Fudan University, Shanghai, People’s Republic of China

https://orcid.org/0000-0003-1910-6465

Jinjie Yu1 Department of Thoracic Surgery, Zhongshan Hospital of Fudan University, Shanghai, People’s Republic of China

https://orcid.org/0000-0002-0027-4007

Tian Jiang1 Department of Thoracic Surgery, Zhongshan Hospital of Fudan University, Shanghai, People’s Republic of China

Siyun Lin1 Department of Thoracic Surgery, Zhongshan Hospital of Fudan University, Shanghai, People’s Republic of China

Shaoyuan Zhang1 Department of Thoracic Surgery, Zhongshan Hospital of Fudan University, Shanghai, People’s Republic of China

https://orcid.org/0000-0002-6187-4313

Lu Lv2 Department of Cardiothoracic Surgery, Affiliated People’s Hospital of Jiangsu University, Jiangsu, People’s Republic of China

Tao Long2 Department of Cardiothoracic Surgery, Affiliated People’s Hospital of Jiangsu University, Jiangsu, People’s Republic of China

Huiwen Pan2 Department of Cardiothoracic Surgery, Affiliated People’s Hospital of Jiangsu University, Jiangsu, People’s Republic of China

Junqing Qi2 Department of Cardiothoracic Surgery, Affiliated People’s Hospital of Jiangsu University, Jiangsu, People’s Republic of China

Qiang Zhou3 Department of Thoracic Surgery, Sichuan Cancer Hospital & Institute, Sichuan, People’s Republic of China

Weifeng Tang4 Department of Cardiothoracic Surgery, Nanjing Drum Tower Hospital, Jiangsu, People’s Republic of China

Guowen Ding2 Department of Cardiothoracic Surgery, Affiliated People’s Hospital of Jiangsu University, Jiangsu, People’s Republic of China

Liming Wang5 Department of Respiratory, Shanghai Xuhui Central Hospital, Shanghai, People’s Republic of China

Lijie Tan1 Department of Thoracic Surgery, Zhongshan Hospital of Fudan University, Shanghai, People’s Republic of China

Jun Yin1 Department of Thoracic Surgery, Zhongshan Hospital of Fudan University, Shanghai, People’s Republic of ChinaCorrespondence[email protected] [email protected]

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The Single Nucleotide Polymorphisms of AP1S1 are Associated with Risk of Esophageal Squamous Cell Carcinoma in Chinese Population

Table 1 Distribution of Selected Demographic Variables and Risk Factors in ESCC Case and Control Groups

Table 2 Primary Information for AP1S1 rs6969685 T>C, rs4727480 A>G, rs77387752 C>T, rs4729666 C>T, rs35208462 C>T

Table 3 Logistic Regression Analyses of Associations Between rs6969685 T>C, rs4727480 A>G, rs77387752 C>T, rs4729666 C>T, rs35208462 C>T and Risk of ESCC

Table 4 Stratified Analyses Between rs77387752 C>T Polymorphism and ESCC Risk by Sex, Age, Smoking Status, and Alcohol Consumption

Table 5 Stratified Analyses Between Rs4729666 C>T Polymorphism and ESCC Risk by Sex, Age, Smoking Status, and Alcohol Consumption

Table 6 Stratified Analyses Between Rs35208462 C>T Polymorphism and ESCC Risk by Sex, Age, Smoking Status, and Alcohol Consumption

Table 7 Haplotype Frequencies in the Case and Control Group, and Risk of ESCC

Table 8 Linkage Disequilibrium Analysis Using Linkage Disequilibrium Parameter D

Table 9 Linkage Disequilibrium Analysis Using Linkage Disequilibrium Parameter r²

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The Single Nucleotide Polymorphisms of AP1S1 are Associated with Risk of Esophageal Squamous Cell Carcinoma in Chinese Population

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Table 1 Distribution of Selected Demographic Variables and Risk Factors in ESCC Case and Control Groups

Table 2 Primary Information for AP1S1 rs6969685 T>C, rs4727480 A>G, rs77387752 C>T, rs4729666 C>T, rs35208462 C>T

Table 3 Logistic Regression Analyses of Associations Between rs6969685 T>C, rs4727480 A>G, rs77387752 C>T, rs4729666 C>T, rs35208462 C>T and Risk of ESCC

Table 4 Stratified Analyses Between rs77387752 C>T Polymorphism and ESCC Risk by Sex, Age, Smoking Status, and Alcohol Consumption

Table 5 Stratified Analyses Between Rs4729666 C>T Polymorphism and ESCC Risk by Sex, Age, Smoking Status, and Alcohol Consumption

Table 6 Stratified Analyses Between Rs35208462 C>T Polymorphism and ESCC Risk by Sex, Age, Smoking Status, and Alcohol Consumption

Table 7 Haplotype Frequencies in the Case and Control Group, and Risk of ESCC

Table 8 Linkage Disequilibrium Analysis Using Linkage Disequilibrium Parameter D

Table 9 Linkage Disequilibrium Analysis Using Linkage Disequilibrium Parameter r2

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Table 9 Linkage Disequilibrium Analysis Using Linkage Disequilibrium Parameter r²