Association of IL-6 and TGF-β Gene Polymorphisms with the Risk of Thoracolumbar Osteoporotic Vertebral Compression Fractures

Figures & data

Table 1 Clinical Information of the Subjects

Indicators	Controls (n=144)	Patients (n=146)	P
Age (years)	70.98 ± 5.84	71.92 ± 4.21	0.114
Gender (n)			0.079
Male/ Female	75/69	61/85
BMI (kg/m^2)	24.69 ±3.20	24.96 ±2.90	0.447
FBG (mg/dL)	109.06 ±27.82	116.43 ±40.78	0.074
SBP (mmHg)	128.51 ±17.01	129.64 ±26.93	0.670
DBP (mmHg)	75.11 ±11.70	76.86 ±13.28	0.235
HDL-C (mg/dL)	49.68 ±17.75	45.42 ±10.46	0.013
LDL-C (mg/dL)	121.09 ±40.13	123.07 ±34.21	0.651
TG (mg/dL)	121.84 ±30.32	143.53 ±48.66	<0.001
BMD (g/cm^2)	−3.29 ±0.67	−3.42 ±0.81	0.141

Note: Data are expressed as n or mean ± standard deviation.

Abbreviations: BMI, body mass index; FBG, fasting blood glucose; SBP, systolic blood pressure; DBP, diastolic blood pressure; HDL-C, high-density lipoprotein cholesterol; LDL-C, low-density lipoprotein cholesterol; BMD, bone mineral density.

Figure 1 The expression levels of IL-6 (A) and TGF-β (B) in controls and patients serum were measured by enzyme-linked immunosorbent assay. ***P < 0.001 versus the Control groups.

Table 2 Frequency Distribution of IL-6 Gene rs1800796 Genotype and Allele in Controls and Patients Groups

Genotype/Allele	Controls, N=144, n (%)	Patients, N=146, n (%)	χ^2	OR (95% CI)	P
rs1800796
CC	73 (50.69)	57 (39.04)	–	1	–
CG	60 (41.67)	61 (41.78)	1.454	1.356 (0.826–2.224)	0.228
GG	11 (7.64)	28 (19.18)	10.103	3.394 (1.560–7.385)	0.001
C	206 (71.53)	175 (59.93)	–	1	–
G	82 (28.47)	117 (40.07)	8.651	1.680 (1.187–2.376)	0.003
P^HWE	0.78

Abbreviations: OR, odds ratio; 95% CI, 95% confidence interval.

Table 3 Frequency Distribution of TGF-β Gene rs1982073 Genotype and Allele in Controls and Patients Groups

Genotype/Allele	Controls, N=144, n (%)	Patients, N=146, n (%)	χ^2	OR (95% CI)	P
rs1982073
CC	32 (22.22)	56 (38.36)	–	1	–
CT	74 (51.39)	61 (41.78)	7.272	0.471 (0.272–0.817)	0.007
TT	38 (26.39)	29 (19.86)	6.362	0.436 (0.228–0.835)	0.012
C	138 (47.92)	173 (59.25)	–	1	–
T	150 (52.08)	119 (40.75)	8.422	0.615 (0.443–0.855)	0.004
P^HWE	0.72

Abbreviations: OR, odds ratio; 95% CI, 95% confidence interval.