One Rare Warfarin Resistance Case and Possible Mechanism Exploration

Figures & data

Figure 1 The trend of warfarin dose and INR.

Abbreviation: INR, international normalized ratio.

Table 1 The results of gene polymorphisms of the patient

SNP ID	Enzymes	SNP Allele	Prediction	Results	Resultant Dose
rs61742245	VKORC1	106G>A	Dosage	GG	Normal dose
rs2108622	CYP4F2	1297G>A	Dosage	GA	Higher dose
rs7200749	VKORC1	248C>T	Dosage	CC	Normal dose
rs55894764	VKORC1	36G>A	Dosage	GG	Normal dose
rs2592551	GGCX	1218C>T	Dosage	CC	Normal dose
rs1057910	CYP2C9	1075A>C	Dosage/toxicity	AA	Normal dose
rs1799853	CYP2C9	430C>T	Dosage	CC	Normal dose
rs9923231	VKORC1	1639A>G	Dosage	AA	Lower dose