Association Between CTSK Gene Polymorphisms and Response to Alendronate Treatment in Postmenopausal Chinese Women with Low Bone Mineral Density

Figures & data

Table 1 Characteristic Changes of 460 Postmenopausal Women in This Study

	Age (Years)	BMI (Kg/m^2)	BMD (g/cm^2)
			Lumbar 1–4	Femoral Neck	Total Hip
Baseline	63.55±12.2	22.81±3.03	0.804±0.197	0.687±0.103	0.725±0.110
1-year of Treatment	64.95±12.2	22.89±3.05	0.858±0.150	0.701±0.103	0.749±0.133
Percent Change (%)	–	–	4.33±6.42	1.85±4.20	2.36±3.79
P-value	–	0.121	<0.001	<0.001	<0.001

Notes: Data presented as mean ± SD. Significant values (P <0.05) are presented in bold.

Abbreviations: BMI, body mass index; BMD, bone mineral density.

Table 2 Information on the 4 SNPs of CTSK Gene in the Study

SNP	Physical Position	Major Allele	Minor Allele	MAF	P-value of HWE
rs12085336	150775780	T	A	0.3341	0.04748
rs12746973	150779401	A	G	0.1034	0.8043
rs4379678	150780582	C	T	0.2457	0.5311
rs10847	150782797	T	C	0.2263	0.6927

Abbreviations: SNP, single nucleotide polymorphism; MAF, minor allele frequency; HWE, Hardy–Weinberg equilibrium.

Table 3 The Association Between 3 SNPs of CTSK Gene and the % Change in BMD

SNP	Lumbar 1–4 (%)		Femoral Neck (%)		Total Hip (%)
	Beta^a	P-value	Beta^a	P-value	Beta^a	P-value
rs12746973	1.289	0.038	−0.513	0.324	0.498	0.249
rs4379678	−0.808	0.071	0.537	0.149	0.076	0.804
rs10847	0.810	0.075	0.792	0.038	0.389	0.217

Note: ^aBetas were estimated using linear regression model with adjustment for age and BMI.

Abbreviations: SNP, single nucleotide polymorphism; BMD, bone mineral density; Beta, regression coefficient.

Table 4 The Association Between 3 SNPs of CTSK Gene and BMD Response

SNP	Lumbar 1–4			Femoral Neck			Total Hip
	OR^a	95% CI	P-value	OR^a	95% CI	P-value	OR^a	95% CI	P-value
rs12746973	1.536	0.963–2.450	0.071	0.785	0.392–1.574	0.496	1.017	0.650–1.591	0.941
rs4379678	0.800	0.580–1.104	0.175	0.887	0.553–1.424	0.620	0.968	0.705–1.330	0.841
rs10847	1.339	0.958–1.872	0.088	1.748	1.123–2.791	0.013	1.334	0.954–1.865	0.092

Note: ^aORs were estimated using unconditional logistic regression model with adjustment for age and BMI.

Abbreviations: SNP, single-nucleotide polymorphism; BMD, bone mineral density; OR, odds ratio; 95% CI, 95% confidence interval.