Figures & data
Table 1 Nongenetic clinical risk factors for statin adverse reactions
Table 2 Recommended dosing of simvastatin based on SLCO1B1 phenotype
Table 3 CYP3A-inhibiting medications
Table 4 Select transport and metabolism proteins by statin type
Figure 1 Representation of the superset of all genes involved in the transport, metabolism and clearance of statin class drugs. ©PharmGKB.37 (Reproduced with permission from the Pharmacogenomics Knowledge Base [PharmGKB] and Stanford University, https://www.pharmgkb.org/pathway/PA145011108)Citation71, Whirl-Carrillo M, McDonagh EM, Hebert JM, et al. Pharmacogenomics knowledge for personalized medicine. Clin Pharmacol Ther. 2012;92(4):414–417. *Active and inactive metabolites are terms generalized to the medication class and may not be applicable to individual statin types.
![Figure 1 Representation of the superset of all genes involved in the transport, metabolism and clearance of statin class drugs. ©PharmGKB.37 (Reproduced with permission from the Pharmacogenomics Knowledge Base [PharmGKB] and Stanford University, https://www.pharmgkb.org/pathway/PA145011108)Citation71, Whirl-Carrillo M, McDonagh EM, Hebert JM, et al. Pharmacogenomics knowledge for personalized medicine. Clin Pharmacol Ther. 2012;92(4):414–417. *Active and inactive metabolites are terms generalized to the medication class and may not be applicable to individual statin types.](/cms/asset/eec44bd2-cb21-49f4-961f-93039d57c48a/dpgp_a_86013_f0001_c.jpg)