The frequency of SLCO1B1*5 polymorphism genotypes among Russian and Sakha (Yakutia) patients with hypercholesterolemia

Figures & data

Table 1 Results of comparison of frequency of C-allele of SLCO1B1, Russian and Sakha (Yakutia) versus published data

Population	n	TT genotype	TC genotype	CC genotype	T allelea	C allelea	Comparison with Russian			Comparison with Sakha (Yakutia)
							Chi-squared	P	OR (95% CI)	Chi-squared	P	OR (95% CI)
Russian Federation, Russians	1,071	665 (62%)	346 (32%)	60 (6%)	1,676 (78%)	466 (22%)	–	–	–	8.9	0.0028	2.2 (1.32–3.70)
Russian Federation, Sakha (Yakutia)	76	62 (82%)	11 (14%)	3 (4%)	135 (89%)	17 (11%)	8.9	0.0028	0.45 (0.27–0.76)	–	–	–
Brazil^Citation11	216	152 (71%)	59 (27%)	5 (2%)	363 (84%)	69 (16%)	7.1	0.0078	0.68 (0.52–0.90)	1.69	0.19	1.5 (0.86–2.66)
China^Citation12	272	205 (75%)	62 (23%)	5 (2%)	472 (87%)	72 (13%)	19.3	<0.0001	0.55 (0.42–0.72)	0.28	0.59	1.2 (0.69–2.13)
China^Citation13	363	256 (71%)	95 (26%)	12 (3%)	607 (83%)	119 (17%)	9.4	0.002	0.70 (0.56–0.88)	2.2	0.136	1.56 (0.91–2.68)
China^Citation14	140	111 (79%)	27 (19%)	2 (2%)	249 (89%)	31 (11%)	16.8	<0.0001	0.45 (0.30–0.66)	0.0013	0.97	0.99 (0.53–1.85)
China^Citation15	373	281 (75%)	82 (22%)	10 (3%)	644 (86%)	102 (14%)	22.6	<0.0001	(0.45–0.72)	0.48	0.49	1.26 (0.73–2.17)
France^Citation16	724	519 (72%)	193 (26.5%)	12 (1.5%)	1,231 (85%)	217 (15%)	25.6	<0.0001	0.63 (0.53–0.75)	1.3	0.25	1.4 (0.83–2.37)
Japan^Citation17	64	44 (73%)	20 (27%)	0 (0%)	108 (84%)	20 (16%)	2.4	0.12	0.66 (0.41–1.08)	0.83	0.36	1.47 (0.73–2.95)

Note:

a Number (allele frequency).

SorticaVAFiegenbaumMLimaLOSLCO1B1 gene variability influences lipid-lowering efficacy on simvastatin therapy in Southern BraziliansClin Chem Lab Med201250344144822505549

 PubMed Web of Science ®Google Scholar

LeeHKHuMLuiSShHoCSWongCKTomlinsonBEffects of polymorphisms in ABCG2, SLCO1B1, SLC10A1 and CYP2C9/19 on plasma concentrations of rosuvastatin and lipid response in Chinese patientsPharmacogenomics201314111283129423930675

 PubMed Web of Science ®Google Scholar

FuQLiYPGaoYLack of association between SLCO1B1 polymorphism and the lipid-lowering effects of atorvastatin and simvastatin in Chinese individualsEur J Clin Pharmacol20136961269127423263738

 PubMed Web of Science ®Google Scholar

YangGPYuanHTangBLack of effect of genetic polymorphisms of SLCO1B1 on the lipid-lowering response to pitavastatin in Chinese patientsActa Pharmacol Sin201031338238620140004

 PubMed Web of Science ®Google Scholar

HuMTomlinsonBEffects of statin treatments and polymorphisms in UGT1A1 and SLCO1B1 on serum bilirubin levels in Chinese patients with hypercholesterolaemiaAtherosclerosis2012223242743222749334

 PubMed Web of Science ®Google Scholar

CouvertPGiralPDejagerSAssociation between a frequent allele of the gene encoding OATP1B1 and enhanced LDL-lowering response to fluvastatin therapyPharmacogenomics2008991217122718781850

 PubMed Web of Science ®Google Scholar

Tachibana-IimoriRTabaraYKusuharaHEffect of genetic polymorphism of OATP-C (SLCO1B1) on lipid-lowering response to HMG-CoA reductase inhibitorsDrug Metab Pharmacokinet200419537538015548849

 PubMedGoogle Scholar