A validated measure of adherence to antibiotic prophylaxis in children with sickle cell disease

Figures & data

Table 1 Demographics

Characteristic	n
Mean age in years (standard deviation, median)	58	2.61 (1.71, 2.07)
Sex, n (%)	58
Male		33 (56.9)
Female		25 (43.1)
Diagnosis, n (%)	58
Hemoglobin SS disease		33 (56.9)
Hemoglobin SC disease		19 (32.8)
S beta thalassemia plus		5 (8.6)
S beta thalassemia zero		1 (1.7)
Patient race/ethnicity, n (%)	58
Black/African–American, non-Hispanic		50 (86.2)
Black/African–American, ethnicity not indicated		5 (8.6)
Other, non-Hispanic		2 (3.4)
Other, Hispanic		1 (1.7)
Father’s country of origin, n (%)	58
USA		47 (81.0)
New Guinea		2 (3.4)
Nigeria		2 (3.4)
Togo		2 (3.4)
Other (one from each: Germany, Ghana, Mali, Puerto Rico, Sudan)		5 (8.6)
Mother’s country of origin, n (%)	58
USA		47 (81.0)
New Guinea		2 (3.4)
Nigeria		2 (3.4)
Togo		2 (3.4)
Other (one from each: Germany, Ghana, Puerto Rico, Sierra Leone, Sudan)		5 (8.6)
Patient’s country of origin, n (%)	58
USA		56 (96.6)
New Guinea		2 (3.4)
Household education, n (%)	57
Less than high school diploma		7 (12.1)
High school graduate		13 (22.4)
Less than 2 years of college		19 (32.8)
Associate’s degree		4 (6.9)
Bachelor’s degree		7 (12.1)
Some graduate school		3 (5.2)
Master’s degree		2 (3.4)
Doctorate degree		2 (3.4)
Person completing the scale, n (%)	58
Mother		52 (89.7)
Father		3 (3.4)
Grandmother		3 (3.4)

Table 2 SCAALE scores and reliability

SCAALE section	Mean	Range	Standard deviation	Internal consistency reliability
Total scale	4.7	3.14–5.00	0.37	0.89
Time	4.5	1.00–5.00	0.80	0.86
Dose	4.9	3.75–5.00	0.24	0.32
Pharmacy	4.6	3.25–5.00	0.44	0.24
Plan	4.4	1.25–5.00	0.81	0.82
Remember	4.7	2.75–5.00	0.49	0.77
Communicate	4.6	1.00–5.00	0.77	0.83
Environment	4.9	4.00–5.00	0.23	0.22

Abbreviation: SCAALE, Sickle Cell Antibiotic Adherence Level Evaluation.

Table 3 Correlations for SCAALE scores and validation measures

SCAALE section	Parent General Adherence Rating	Provider General Adherence Rating	Medication possession ratio
Total scale	0.687**	0.441*	0.463**
Time	0.723**	0.331	0.361*
Dose	0.315*	0.389*	0.231
Pharmacy	0.191	0.188	0.015
Plan	0.691**	0.480**	0.437**
Remember	0.471**	0.131	0.140
Communicate	0.230	0.338	0.298
Environment	0.434**	0.081	0.364*

Notes:

* P<0.05;

** P<0.01.

Abbreviation: SCAALE, Sickle Cell Antibiotic Adherence Level Evaluation.

Table S1 SCAALE intercorrelations between subscales

SCAALE section	Time	Dose	Pharmacy	Plan	Remember	Communicate	Environment	Total
Time	1	0.426**	0.361**	0.720**	0.654**	0.144	0.626**	0.846**
Dose	0.426**	1	0.409**	0.384**	0.250	0.093	0.357**	0.518**
Pharmacy	0.361**	0.409**	1	0.432**	0.262*	0.079	0.303*	0.551**
Plan	0.720**	0.384**	0.432**	1	0.536**	0.331*	0.435**	0.869**
Remember	0.654**	0.250	0.262*	0.536**	1	0.127	0.515**	0.701**
Communicate	0.144	0.093	0.079	0.331*	0.127	1	0.160	0.500**
Environment	0.626**	0.357**	0.303*	0.435**	0.515**	0.160	1	0.638**
Total	0.846**	0.518**	0.551**	0.869**	0.701**	0.500**	0.638**	1

Notes:

* Correlation is significant at the 0.05 level (two-tailed t-test);

** correlation is significant at the 0.01 level (two-tailed t-test).

Abbreviation: SCAALE, Sickle Cell Antibiotic Adherence Level Evaluation.