Is it appropriate regarding patient preference to take Myrtol standardized enteric-coated soft capsules after a meal rather than at fasted state? A food–drug pharmacokinetic interaction study in healthy Chinese volunteers

Ting-Ting Zhao1 Department of Pharmacy

Ling-Ling Zhu2 VIP Care Ward, Division of Nursing, The Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, People’s Republic of ChinaCorrespondence[email protected]

Meng Chen1 Department of Pharmacy

Quan Zhou1 Department of PharmacyCorrespondence[email protected]

Figures & data

Figure 1 Chemical structures of eucalyptol and linalool (internal standard).

Figure 2 MRM chromatograms of eucalyptol and IS.

Notes: (A) Blank plasma; (B) Blank plasma spiked with IS (final concentration: 1 μg/mL); (C) standard sample of eucalyptol (100 ng/mL) spiked with IS; (D) healthy volunteer plasma sample 4.0 h after an oral dose of 300 mg Myrtol standardized capsules, spiked with IS
Abbreviations: IS, internal standard; MRM, multiple reaction monitoring; min, minutes; h, hours.

Figure 3 Concentration–time curves of eucalyptol after a single oral dose (300 mg) of Myrtol standardized capsules taken at fasted and fed states in 11 Chinese volunteers (mean ± standard deviation).

Abbreviation: h, hours.

Table 1 The pharmacokinetic parameters of eucalyptol after a single oral dose of Myrtol standardized capsules taken at fasted and fed states in 11 Chinese volunteers

Download CSV Display Table

Table 2 ANOVA for the assessment of the pretreatment, subject and period effects, and 90% CI for the fasted/fed ratio of C_max, AUC_0–t, and AUC_0–∞, using logarithmic transformed data, after a single dose of Myrtol standardized capsules to 11 Chinese volunteers (α=0.05)

Download CSV Display Table

Is it appropriate regarding patient preference to take Myrtol standardized enteric-coated soft capsules after a meal rather than at fasted state? A food–drug pharmacokinetic interaction study in healthy Chinese volunteers

Table 1 The pharmacokinetic parameters of eucalyptol after a single oral dose of Myrtol standardized capsules taken at fasted and fed states in 11 Chinese volunteers

Table 2 ANOVA for the assessment of the pretreatment, subject and period effects, and 90% CI for the fasted/fed ratio of C_max, AUC_0–t, and AUC_0–∞, using logarithmic transformed data, after a single dose of Myrtol standardized capsules to 11 Chinese volunteers (α=0.05)

Information for

Open access

Opportunities

Help and information

Your download is now in progress and you may close this window

Login or register to access this feature

Is it appropriate regarding patient preference to take Myrtol standardized enteric-coated soft capsules after a meal rather than at fasted state? A food–drug pharmacokinetic interaction study in healthy Chinese volunteers

Figures & data

Table 1 The pharmacokinetic parameters of eucalyptol after a single oral dose of Myrtol standardized capsules taken at fasted and fed states in 11 Chinese volunteers

Table 2 ANOVA for the assessment of the pretreatment, subject and period effects, and 90% CI for the fasted/fed ratio of Cmax, AUC0–t, and AUC0–∞, using logarithmic transformed data, after a single dose of Myrtol standardized capsules to 11 Chinese volunteers (α=0.05)

Related research

To cite this article:

Download citation

Information for

Open access

Opportunities

Help and information

Keep up to date

Table 2 ANOVA for the assessment of the pretreatment, subject and period effects, and 90% CI for the fasted/fed ratio of C_max, AUC_0–t, and AUC_0–∞, using logarithmic transformed data, after a single dose of Myrtol standardized capsules to 11 Chinese volunteers (α=0.05)