Adverse events and patients’ perceived health-related quality of life at the end of multidrug-resistant tuberculosis treatment in Namibia

Figures & data

Figure 1 Boxplots comparing the variation in HRQoL scores for each SF-8 item.

Notes: Physical component: PF, RP, GH, and BP. Mental component: VT, SF, RE, and MH.
Abbreviations: HRQoL, health-related quality of life; SF-8, Short Form-8™ questionnaire; PF, physical functioning; RP, role physical; GH, general health; BP, bodily pain; VT, vitality; SF, social functioning; RE, role emotional; MH, mental health.

Figure 2 Correlation of the physical and mental component scores.

Abbreviations: MCS, mental component summary; PCS, physical component summary.

Table 1 Frequency of patients’ self-reported adverse events

Adverse event	Patients reporting (N=36), n (%)
Hearing loss	9 (25)
Vomiting	8 (22)
Joint pain	8 (22)
Nausea	7 (19)
Tinnitus	6 (17)
Dizziness	6 (17)
Abdominal pain	6 (17)
Headache	5 (14)
Fatigue	5 (14)
Vision problems	4 (11)

Figure 3 Patients’ mean HRQoL scores by number of adverse events experienced by the patients.

Abbreviation: HRQoL, health-related quality of life.

Table 2 Occurrence of adverse events and patients’ rating of their HRQoL

Type of adverse event	Categories	Proportion of patients with HRQoL scores <50, n (%)	P-value (Fisher’s exact test)
Any adverse event	0–2 events	3/17 (18)	0.45
	≥3 events	6/19 (32)
Ototoxicity (hearing loss and tinnitus)	Absent	6/20 (30)	0.70
	Present	3/16 (19)
Gastrointestinal eventsa	Absent	6/22 (27)	1.00
	Present	3/14 (21)
Joint pain and neuropathy	Absent	5/25 (20)	0.41
	Present	4/11 (36)

Note:

a Includes nausea, vomiting, abdominal pain, and diarrhea.

Abbreviation: HRQoL, health-related quality of life.

Figure S1 The three supplemental questions on the occurrence of adverse events during MDR-TB treatment.

Abbreviation: MDR-TB, multidrug-resistant tuberculosis.