“Open mesh” or “strictly selected population” recruitment? The experience of the randomized controlled MeMeMe trial

Figures & data

Table 1 Baseline characteristics of the 420 volunteers randomized to metformin/placebo within the whole population enrolled in MeMeMe trial⁸

Characteristic	Placebo (207) (mean ± SD)	Metformin (213) (mean ± SD)	P-value*
Age (years)	63.32±3.68	64.29±5.13	0.10
Sex (n, %)	Male (75, 36%)	Male (71, 33%)
	Female (132, 64%)	Female (142, 67%)
Weight (kg)	87.25±16.98	84.39±14.76	0.094
Waist circumference (cm)	100.04±12.29	98.74±10.79	0.29
Diastolic pressure (mmHg)	88.77±9.39	89.42±9.08	0.51
Systolic pressure (mmHg)	144.57±16.1	150.18±34.7	0.053
Glycemia (mg/dL)	103.58±10.21	103.59±10.0	0.99
Total cholesterol (mg/dL)	215.44±36.80	215.94±38.56	0.90
HDL (mg/dL)	52.87±13.13	58.13±15.09	<0.01
LDL (mg/dL)	135.36±33.11	133.43±35.2	0.60
Triglycerides (mg/dL)	135.94±62.11	131.18±55.67	0.08
AST (IU/L)	22.16±18.20	20.61±6.50	0.29
ALT (IU/L)	26.12±13.27	23.12±10.53	0.02
GammaGT (IU/L)	33.11±25.37	31.24±20.67	0.45
Education (n, %)
Junior high school	(46, 22%)	(49, 23%)	0.20
High school	(120, 58%)	(132, 62%)
University	(41, 20%)	(32, 15%)
Working/retired (n, %)
Working	(139, 67%)	(149, 70%)	0.98
Retired	(68, 33%)	(64, 30%)

Notes:

* Student’s t-test P-value for continuous variables, chi-squared test P-value for qualitative variables. Statistically significant values are shown in bold.

Abbreviations: HDL, high-density lipoprotein; LDL, low-density lipoprotein.

Figure 1 Kaplan–Meier estimator of participants who withdrew from MeMeMe trial.⁸

Note: The red line refers to the metformin group, green to placebo.

Table 2 Baseline characteristics of the 23 people who dropped out after randomization by group

Characteristic	Placebo (10) (mean ± SD)	Metformin (13) (mean ± SD)	P-value*
Age (years)	54.67±5.43	56.78±7.0	0.52
Sex (n, %)	Male (2, 20%)	Male (1, 8%)
	Female (8, 80%)	Female (12, 92%)
Weight (kg)	85.63±17.35	85.86±16.95	0.91
Waist circumference (cm)	96.68±13.01	99.18±12.36	0.10
Diastolic pressure (mmHg)	90.83±10.63	86.33±14.43	0.50
Systolic pressure (mmHg)	144.67±19.53	135.56±31.44	0.50
Glycemia (mg/dL)	97.5±7.56	98.44±7.0	0.81
Total cholesterol (mg/dL)	196.5±28.87	217±25.56	0.19
HDL (mg/dL)	56.0±15.62	57.4±15.94	0.46
LDL (mg/dL)	121.83±30.45	136.89±27.02	0.35
Triglycerides (mg/dL)	99.50±42.64	102.55±45.46	0.90
AST (IU/L)	23.67±6.81	20.78±6.83	0.44
ALT (IU/L)	28.5±14.31	27.67±18.92	0.92
GammaGT (IU/L)	30.83±15.52	31.88±17.78	0.91
Education (n, %)
Junior high school	(2, 20%)	(3, 23%)	0.17
High school	(6, 60%)	(9, 69%)
University	(2, 20%)	(1, 8%)
Working/retired (n, %)
Worker	(7, 70%)	(10, 69%)	0.99
Retired	(3, 30%)	(3, 31%)

Note:

* Student’s t-test P-value for continuous variables, chi-squared test P-value for qualitative variables.

Abbreviations: HDL, high-density lipoprotein; LDL, low-density lipoprotein.

PasanisiPGarganoGDi MauroMGA randomized controlled trial of Mediterranean diet and metformin to prevent age-related diseases in people with metabolic syndromeTumori Epub2017120

 Web of Science ®Google Scholar