An upper and lower bound of the Medication Possession Ratio

Figures & data

Figure 1 Three different ways for calculating the MPR value.

Notes: (A) Fixed MPR with days’ supply of the last acquisition falling within the time interval. (B) Fixed MPR with days’ supply beyond the time interval being truncated. (C) Variable MPR.
Abbreviations: FMPR, Fixed MPR; MPR, Medication Possession Ratio; VMPR, Variable MPR; Rx, prescription fill.

Figure 2 (A) Histogram of acquisition quantities (n=212,875). (B) Histogram of days between two subsequent acquisitions (n=193,328). (C) Cross-correlation correlogram of both histograms.

Abbreviation: Rx, prescription fill.

Figure 3 VMPRm and FMPR trends together with their sample sizes as well as the weighted average.

Abbreviations: avg, average; FMPR, Fixed MPR; MPR, Medication Possession Ratio; VMPR, Variable MPR; VMPRm, Variable MPR modified.

Figure 4 (A) FMPR trends for patients with different numbers of acquisitions. (B) VMPRm trends for patients with different numbers of acquisitions. Note that trends have been truncated when the sample number is below 3% of the initial sample number (25,724).

Abbreviations: FMPR, Fixed MPR; MPR, Medication Possession Ratio; VMPR, Variable MPR; VMPRm, Variable MPR modified.

Figure 5 FMPR trends for different minimum numbers of acquisitions.

Abbreviation: FMPR, Fixed Medication Possession Ratio.

Figure 6 Histograms of individual (A) FMPR values and (B) VMPRm values for a time interval of 365 days after the patient’s index date and without capping at one.

Abbreviations: FMPR, Fixed MPR; MPR, Medication Possession Ratio; VMPR, Variable MPR; VMPRm, Variable MPR modified.