Patient and oncologist preferences for attributes of treatments in advanced melanoma: a discrete choice experiment

Figures & data

Table 1 Attributes and levels in the discrete choice experiment

Attribute	No	Levels
Mode of administration	1	Oral – a medication taken by mouth for a period of time
	2	Intravenous – an infusion given into the vein for a period of time
	3	Subcutaneous-shot given under the skin using a short needle to inject a drug into the tissue layer between the skin and the muscle
Dosing schedule	1	Two medicines; one medicine is taken twice daily, the other once daily
	2	One medicine taken once daily
	3	One medicine taken twice daily
	4	One medicine taken by 30-minute infusion every 3 weeks
	5	One medicine taken by 60-minute infusion every 2 weeks
	6	One medicine taken by 90-minute infusion every 3 weeks
	7	Two medicines, both are given as a 150-minute infusion every 3 weeks for 3 months (plus/minus: one of the two medicines is continued as 60-minute infusion every 2 weeks for 5 or more months)
	8	One medicine given by one injection every 3 weeks
Median duration of therapy	1	3 months
	2	8 months
	3	12 months
Objective response rate	1	15 out of 100 patients (15% chance of responding)
	2	33 out of 100 patients (33% chance of responding)
	3	65 out of 100 patients (65% chance of responding)
Progression-free survival	1	3 months
	2	5 months
	3	11.5 months
Overall survival	1	45 out of 100 patients (45% of patients survive to 12 months)
	2	55 out of 100 patients (55% of patients survive to 12 months)
	3	75 out of 100 patients (75% of patients survive to 12 months)
Grade 3/4 adverse events	1	10 out of 100 patients (10% likelihood of experiencing a serious side effect)
	2	32 out of 100 patients (32% likelihood of experiencing a serious side effect)
	3	55 out of 100 patients (55% likelihood of experiencing a serious side effect)

Figure 1 Example of patient discrete choice experiment task.

Abbreviation: IV, intravenous.

Figure 2 Example of oncologist discrete choice experiment task.

Abbreviations: BRAF, B-Raf; ECOG PS, Eastern Cooperative Oncology Group Performance Status; IV, intravenous; LDH, lactic acid dehydrogenase.

Figure 3 Relative preference weights for patients and oncologists, as estimated by Hierarchical Bayesian logistic regression models with effects coding.

Abbreviations: AEs, adverse events; DS, dosing schedule; IV, intravenous; MDT, median duration of therapy; MoA, mode of administration; med, medication; OS, overall survival; ORR, objective response rate; PFS, progression-free survival.

Figure 4 Relative importance of attributes for patients and oncologists.

Abbreviations: AEs, adverse events; DS, dosing schedule; MDT, median duration of therapy; MoA, mode of administration; ORR, objective response rate; OS, overall survival; PFS, progression-free survival.