Comparison of three types of central venous catheters in patients with malignant tumor receiving chemotherapy

Figures & data

Table 1 Patient demographic characteristics of three types of CVCs

Variables	Port	PICC	NTC	P-value
Median age, years	52.20	52.38	51.73	0.978
Gender				0.663
Male	20	25	14
Female	25	35	26
Cancer diagnosis				0.801
Breast cancer	18	22	16
Lung cancer	12	18	12
GI cancer	13	14	11
Others	2	6	1
Cancer stage				0.355
I	0	2	2
II	7	14	12
III	23	21	13
IV	25	23	13
Chemotherapeutic agent				0.541
CAF	2	4	1
DCF	2	6	1
FOLFIRI	4	4	2
FOLFOX	7	6	4
GP	3	4	4
GT	3	1	0
NP	3	8	1
PF	0	1	1
PP	2	6	3
TAC	10	10	9
TF	0	0	1
TP	9	10	13

Abbreviations: CVC, central venous catheter; PICC, peripherally inserted central catheter; NTC, non-tunneled central venous catheter; GI, gastrointestinal; CAF, cyclophosphamide + anthracycline + fluorouracil; DCF, docetaxel + cisplatin + fluorouracil; FOLFIRI, irinotecan + leucovorin + fluorouracil; FOLFOX, oxaliplatin + leucovorin + fluorouracil; GP, gemcitabine + platinum; GT, gemcitabine + taxane; NP, navelbine + platinum; PF, platinum + fluorouracil; PP, pemetrexed + platinum; TAC, taxane + anthracycline + cyclophosphamide; TF, taxane + fluorouracil; TP, taxane + platinum.

Table 2 The duration time of three types of CVCs

Group	Mean time (days)	DT ≤6M	6M < DT <12M	DT ≥12M	n	P-value
Port	338.3±93.8	2	22	21	45	0.000
PICC	261.1±63.6	8	48	4	60
NTC	119.9±33.2	35	5	0	40

Abbreviations: CVC, central venous catheter; DT, duration time; M, month; PICC, peripherally inserted central catheter; NTC, non-tunneled central venous catheter.

Figure 1 Kaplan–Meier survival analysis curve for time to catheter removal (all removals including treatment completion, death, and complications) by the type of CVCs.

Abbreviations: CVC, central venous catheter; PICC, peripherally inserted central catheter; NTC, non-tunneled central venous catheter.

Table 3 Complications of the three types of CVCs

Group	Phlebitis	Thrombosis	Infection	Malposition	Occlusion	Breakage	Total, n (%)
Port	0	0	0	0	1	0	1 (2.2)
PICC	10	8	2	0	3	1	24 (40)
NTC	0	2	5	2	2	0	11 (27.5)

Notes: Port vs PICC, P<0.01; port vs NTC, P<0.01; PICC vs NTC, P>0.05.

Abbreviations: CVC, central venous catheter; PICC, peripherally inserted central catheter; NTC, non-tunneled central venous catheter.

Table 4 Cost of different types of CVCs in different duration times

Group	Average cost		Average cost for DT ≤6M		Average cost for 6M < DT < 12M		Average cost for DT ≥12M
	n	$	n	$	n	$	n	$
Port	45	1,449.0±54.3	2	1,349.2±2.3	22	1,412.4±27.9	21	1,496.8±28.5
PICC	60	1,089.3±160.5	8	838.2±26.2	48	1,102.1±102.0	4	1,437.9±94.7
NTC	40	437.9±82.0	35	413.3±52.1	5	609.8±15.9	0	NA

Notes: Average cost: port vs PICC: P<0.01; port vs NTC, P<0.01; PICC vs NTC, P<0.01. Average cost for DT ≤6M: port vs PICC, P<0.01; port vs NTC, P<0.01; PICC vs NTC, P<0.01. Average cost for 6M <DT <12M: port vs PICC, P<0.01; port vs NTC, P<0.01; PICC vs NTC, P<0.01. Average cost for DT ≥12M: port vs PICC, P>0.05.

Abbreviations: CVC, central venous catheter; DT, duration time; M, month; PICC, peripherally inserted central catheter; NTC, non-tunneled central venous catheter; NA, not available.

Table 5 Quality of life, comfort, and satisfaction of different types of CVCs

Group	Average score	Discomfort	Medium comfort	Comfort	Not satisfied	Satisfied, n (%)
Port	23.9±6.1	8	10	22	2	41 (95.3)
PICC	15.1±5.7	40	14	6	10	50 (83.3)
NTC	14.2±4.0	30	15	0	18	22 (55)

Notes: Average score, port vs PICC, P<0.01; PICC vs NTC, P<0.01. Satisfaction, port vs PICC, P<0.01; PICC vs NTC, P<0.01.

Abbreviations: CVC, central venous catheter; PICC, peripherally inserted central catheter; NTC, non-tunneled central venous catheter.