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Patient Preference and Adherence Volume 12, 2018 - Issue
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Original Research

Comparison of claims vs patient-reported adherence measures and associated outcomes among patients with nonvalvular atrial fibrillation using oral anticoagulant therapy

Judith J Stephenson1 HealthCore, Inc., Wilmington, DECorrespondence[email protected]
,
Mayura U Shinde1 HealthCore, Inc., Wilmington, DE
,
Winghan Jacqueline Kwong2 Daiichi Sankyo, Inc., Basking Ridge, NJ
,
An-Chen Fu1 HealthCore, Inc., Wilmington, DE
,
Hiangkiat Tan1 HealthCore, Inc., Wilmington, DE
&
William S Weintraub3 Christiana Care Health System, Newark, DE, USA
Pages 105-117 | Published online: 12 Jan 2018

Figures & data

Figure 1 Overall study design diagram.

Abbreviation: HIRD, HealthCore Integrated Research Database.
Figure 1 Overall study design diagram.

Table 1 Demographic characteristics overall and by OAC cohort at initial survey

Table 2 Clinical characteristics overall and by OAC cohort at initial survey

Table 3 Claims-determined comorbidities, stroke, and bleeding risk scores overall and by OAC cohort for the 12-month period before the initial survey

Table 4 Number of surveys completed per respondent and mean MMAS-8 and DASS scores by survey and OAC cohort for the 12-month period including and following the initial survey

Table 5 Comparison of adherence measured using PDC and the mean MMAS scores among NVAF patients with OAC therapy for the 12-month period including and after the initial survey

Figure 2 All-cause health care resource utilizationa between adherent and nonadherent patients using PDC calculated from claims for the 12-month period including and after the initial survey.

Notes: aUnadjusted results; *p<0.05; PDCAdherent n=323, PDCNonadherent n=352.
Abbreviations: PDC, proportion of days covered; INP, inpatient; ER, emergency room.
Figure 2 All-cause health care resource utilizationa between adherent and nonadherent patients using PDC calculated from claims for the 12-month period including and after the initial survey.

Figure 3 All-cause health care resource utilizationa between adherent and nonadherent patients using mean MMAS-8 scores determined from patient self-report for the 12-month period including and after the initial survey.

Notes: aUnadjusted results; *p<0.05; MMASAdherent n=251, MMASNonadherent n=424. Use of the ©MMAS is protected by US copyright laws. Permission for use is required. A license agreement is available from: Donald E Morisky, ScD, ScM, MSPH, Professor, Department of Community Health Sciences, UCLA School of Public Health, 650 Charles E. Young Drive South, Los Angeles, CA 90095-1772, USA.
Abbreviations: MMAS-8, Morisky Medication Adherence Scale 8-item; INP, inpatient; ER, emergency room.
Figure 3 All-cause health care resource utilizationa between adherent and nonadherent patients using mean MMAS-8 scores determined from patient self-report for the 12-month period including and after the initial survey.

Figure 4 Comparison of all-cause, stroke-related, and bleeding-related total medical costsa between adherent and nonadherent patients using PDC calculated from claims for the 12-month period including and after the initial survey.

Notes: aUnadjusted results; *p<0.05; PDCAdherent n=323, PDCNonadherent n=352.
Abbreviation: PDC, proportion of days covered.
Figure 4 Comparison of all-cause, stroke-related, and bleeding-related total medical costsa between adherent and nonadherent patients using PDC calculated from claims for the 12-month period including and after the initial survey.

Figure 5 Comparison of all-cause, stroke-related, and bleeding-related total medical costsa between adherent and nonadherent patients using mean MMAS-8 scores determined from patient self-report for the 12-month period including and following the initial survey.

Notes: aUnadjusted results; MMASAdherent n=251, MMASNonadherent n=424. Use of the ©MMAS is protected by US copyright laws. Permission for use is required. A license agreement is available from: Donald E Morisky, ScD, ScM, MSPH, Professor, Department of Community Health Sciences, UCLA School of Public Health, 650 Charles E. Young Drive South, Los Angeles, CA 90095-1772, USA.
Abbreviation: MMAS-8, Morisky Medication Adherence Scale 8-item.
Figure 5 Comparison of all-cause, stroke-related, and bleeding-related total medical costsa between adherent and nonadherent patients using mean MMAS-8 scores determined from patient self-report for the 12-month period including and following the initial survey.

Figure 6 Comparison of all-cause total medical costs by type of services between adherent and nonadherent patients using PDC and mean overall MMAS-8 scores for the 12-month period including and following the initial survey.

Notes: *p<0.05 vs nonadherent PDC cohort; PDCAdherent n=323, PDCNonadherent n=352, MMASAdherent n=251, MMASNonadherent n=424. Use of the ©MMAS is protected by US copyright laws. Permission for use is required. A license agreement is available from: Donald E Morisky, ScD, ScM, MSPH, Professor, Department of Community Health Sciences, UCLA School of Public Health, 650 Charles E. Young Drive South, Los Angeles, CA 90095-1772, USA.
Abbreviations: PDC, proportion of days covered; MMAS-8, Morisky Medication Adherence Scale 8-item.
Figure 6 Comparison of all-cause total medical costs by type of services between adherent and nonadherent patients using PDC and mean overall MMAS-8 scores for the 12-month period including and following the initial survey.

Figure 7 Comparison of Duke Anticoagulation Satisfaction Scale (DASS) mean scores between adherent and nonadherent patients using PDC and mean overall MMAS-8 scores for the 12-month period including and following the initial survey.

Notes: *p<0.05 vs MMAS nonadherent cohort; PDCAdherent n=323, PDCNonadherent n=352, MMASAdherent n=251, MMASNonadherent n=424. Use of the ©MMAS is protected by US copyright laws. Permission for use is required. A license agreement is available from: Donald E Morisky, ScD, ScM, MSPH, Professor, Department of Community Health Sciences, UCLA School of Public Health, 650 Charles E. Young Drive South, Los Angeles, CA 90095-1772, USA.
Abbreviations: PDC, proportion of days covered; MMAS-8, Morisky Medication Adherence Scale 8-item.
Figure 7 Comparison of Duke Anticoagulation Satisfaction Scale (DASS) mean scores between adherent and nonadherent patients using PDC and mean overall MMAS-8 scores for the 12-month period including and following the initial survey.

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