Improvement of psychological status after infliximab treatment in patients with newly diagnosed Crohn’s disease

Figures & data

Figure 1 Participant flow diagram.

Table 1 Demographics of participants

Variable	n (%)
Gender
Male	45 (54.9)
Female	37 (45.1)
Marital status
Married	57 (69.5)
Single	25 (30.5)
Age at diagnosis (A)
≤16 years (A1)	0 (0.0)
17–40 years (A2)	60 (73.2)
>40 years (A3)	22 (26.8)
Location (L)
Terminal ileum (L1)	35 (42.7)
Colon (L2)	17 (20.7)
Ileocolon (L3)	30 (36.6)
Upper gastrointestinal tract (L4)	5 (6.1)
Behavior (B)
Nonpenetrating nonstenosing (B1)	71 (86.6)
Stenosing (B2)	0 (0.0)
Penetrating (B3)	11 (13.4)
Fistula history	33 (40.2)
Gastrointestinal surgery history	9 (13.1)
Smoking or alcohol history	12 (9.2)
IBD family history	3 (2.3)

Abbreviation: IBD, inflammatory bowel disease.

Table 2 Infliximab responders: significance of change in questionnaire scores

Variable	Baseline, n=59	Week 14, n=59	P-value	Baseline, n=58	Week 30, n=58	P-value
Illness perceptions	44.59±12.23	36.75±12.01	<0.001	45.22±12.07	35.47±11.30	<0.001
Emotion-focused coping	18.46±5.16	19.42±4.41	0.063	17.95±4.95	18.59±5.19	0.337
Problem-focused coping	14.19±2.75	13.86±3.07	0.346	14.07±2.77	13.60±3.64	0.329
Maladaptive coping	11.95±6.43	9.97±6.25	0.005	11.78±6.59	9.67±6.18	0.004
Anxiety	10.02±2.14	8.44±1.64	<0.001	10.03±2.09	8.16±1.82	<0.001
Depression	9.05±2.46	8.10±2.08	0.004	9.00±2.36	8.02±1.95	0.004
Quality of life	153.66±27.06	187.41±22.54	<0.001	151.38±26.66	192.10±23.11	<0.001

Note: Data shown as mean ± standard deviation or P-value.

Table 3 Infliximab nonresponders: significance of change in questionnaire scores

Variable	Baseline, n=23	Week 14, n=23	P-value	Baseline, n=24	Week 30, n=24	P-value
Illness perceptions	51.13±9.57	49.13±11.93	0.170	49.33±11.06	47.79±10.95	0.391
Emotion-focused coping	19.61±4.73	17.87±4.77	0.053	20.79±4.78	19.54±4.96	0.346
Problem-focused coping	14.61±2.71	13.39±3.31	0.111	14.88±2.61	13.63±3.32	0.121
Maladaptive coping	13.57±5.92	12.39±5.16	0.241	13.92±5.35	12.54±5.70	0.097
Anxiety	10.57±2.11	10.26±2.20	0.573	10.50±2.23	9.83±1.47	0.141
Depression	8.83±2.04	9.13±2.40	0.585	8.96±2.33	9.75±2.31	0.089
Quality of life	137.48±24.24	146.17±23.41	0.104	143.67±28.13	149.42±21.79	0.284

Note: Data shown as mean ± standard deviation or P-value.