Cost of surgical intervention for reconstructive therapy of HIV-associated facial lipoatrophy

Figures & data

Table 1 Baseline characteristics

	All	Low severity	High severity	P-value
N	66	29	37
Sex
Male n (%)	56 (84.8)	21	35	0.017^a
Age
Mean ± SD	44.48 ± 5.8	43.41 ± 5.481	45.32 ± 5.991	0.58^b
Median (IQR)	43.00 (42–47)	43.00 (40.0–46.5)	43.00 (42.0–48.5)
Risk factor n (%)
Homosexual	26 (33.3)	12	14	0.904^a
Drug user	18 (39.4)	7	11
Heterosexual	22 (27.3)	10	12
CD4
Mean ± SD	663.53 ± 320.874	707.03 ± 333.331	629.43 ± 311.067	0.629^b
Median (IQR)	602.50 (437.75–799.50)	626.00 (445.5–849.5)	565.00 (403.5–737.0)
HIV RNA (log)
Mean ± SD	1.9677 ± 69354	1.8519 ± 0.53101	2.0584 ± 9367	0.38^b
Median (IQR)	1.69 (1.69–1.69)	1.69 (1.69–1.69)	1.69 (1.69–1.86)
Stage n (%)
CDC A	6.00 (9.10)	4	2	0.737^a
CDC B	36.00 (54.6)	16	20
CDC C	24.00 (36.4)	9	15
Time from HIV diagnosis (years)
Mean ± DS	12.86 ± 4.917	12.72 ± 4.165	12.97 ± 5.490	0.126^b
Median (IQR)	12.00 (10.00–15.25)	12.00 (10.5–15.5)	12.00 (9.5–16.5)
Time from lipodystrophy syndrome
Mean ± SD	5.14 ± 2.259	5.00 ± 2.171	5.24 ± 2.350	0.742^b
Median (IQR)	5.00 (3.00–6.25)	5.00 (3.0–6.5)	5.00 (3.0–6.5)
Years on ART
Mean ± SD	9.45 ± 2.943	9.33 ± 2.707	9.55 ± 3.149	0.606^b
Median (IQR)	10.00 (7.875–10.250)	10.00 (7.5–10.5)	10.00 (7.75–10.5)

Notes:

a χ² test;

b Student’s t-test.

Abbreviations: ART, antiretroviral therapy; CDC, Centers for Disease Control and Prevention stage; HIV, human immunodeficiency virus; IQR, interquartile range; RNA, ribonucleic acid; SD, standard deviation.

Table 2 Facial lipoatrophy severity score at baseline

	Surgeon reported	Patient reported
Grade 2	10	38
Grade 3	19	28
Grade 4	31
Grade 5	6

Table 3 Cost and utilization of fillers

	All	PAIG	PLA	P-value^a
N of fillers	531	296^b	235
Median fillers (IQR)	8.0 (6–10)	9.5 (7.75–10)	7.0 (6–9)	0.03
Total costs of filler	128742.45	79392.45	49350.00
Median cost of filler	1890(1417–2650.5)	2517.97(2054.13–2710.35)	1470.00 (1260–1890)	0.00
(IQR) min–max		795.15–3790.00	840.0–2730.0

Notes: Cost is in Euros.

a Mann–Whitney test;

b 296 = Aquamid 249 and AquamidR = 47.

Abbreviations: IQR, interquartile range; PAIG, polyacrylamide gel; PLA, poly-L-lactic acid.

Table 4 Cost and C/E ratios

	All	Low severity	High severity	P-value^a
Total cost	140,416	50,469.76	89,946.39	0.00
Cost
Median (IQR)	2126.04 (1599.90–2822.17)	1641.67 (1326.67–2126.04)	2557.12 (1939.34–2872.04)	0.00
C/E ratio (physician)
Median (IQR)	25.13 (16.41–32.83)	17.19 (13.26–25.00)	28.82 (23.23–37.62)	0.00
C/E ratio (patient)
Median (IQR)	28.62 (18.50–38.80)	23.57 (14.53–33.60)	31.47 (23.03–41.19)	0.03

Notes: Cost is in Euros.

a Mann–Whitney test.

Abbreviations: C/E, cost/efficacy; IQR, interquartile range.