Effectiveness and cost-effectiveness of a multicomponent intervention to improve medication adherence in people with depressive disorders – MAPDep: a study protocol for a cluster randomized controlled trial

Figures & data

Figure 1 Flowchart of MAPDep study procedures.

Notes: ^*Patients: Demographic data, history of depression, depression health status, DAI-10, MHLC-C, HPRS, CPS, BMQ, adherence, BDI-II, HADS, SF-12, EQ-5D-5L; healthcare utilization and productivity losses (collected information will cover the six-month period prior to the study). Psychiatrists: Demographic data, years in practice, professional profile, PPOS and LATCon II.
Abbreviations: BDI-II, Beck Depression Inventory-II; BMQ, Beliefs about Medicines Questionnaire; CMHU, Community Mental Health Unit; CPS, Control Preferences Scale; DAI-10, Drug Attitude Inventory – 10 Items; EQ-5D-5L, EuroQol-5D-5L; HADS, Hospital Anxiety and Depression Scale; HPRS, Hong Psychological Reactance Scale; LATCon II, Leeds Attitude Towards Concordance II Scale; MHLC-C, Multidimensional Health Locus of Control, Form C; PPOS, Patient-Practitioner Orientation Scale; SF-12, Short Form-12.

Table 1 Outcome measurements

Time	Outcome measurements
Patients
T1	Demographic data, history of depression, depression health status
1. Instruments used for self-reported outcomes measures
T1	DAI-10, MHLC-C, HPRS, CPS, BMQ
T1, T2, T3, T4	Adherence, BDI-II, HADS
T1, T3, T4	SF-12, EQ-5D-5L
2. Health care utilization
T1, T3, T4	Visits to mental health services and primary care services, medication and doses, hospital admissions and length of stay, productivity lossesa
Psychiatrists
T1	Demographic data, years in practice, professional profile
T1, T4	PPOS, LATCon II

Notes: T1: baseline; T2: 3 months; T3: 6 months; T4: 12 months.

a Information collected at baseline will cover the 6-month period prior to the study.

Abbreviations: BDI-II, Beck Depression Inventory-II; BMQ, Beliefs about Medicines Questionnaire; CPS, Control Preferences Scale; DAI-10, Drug Attitude Inventory–10 Items; EQ-5D-5L, EuroQol-5D-5L; HADS, Hospital Anxiety and Depression Scale; HPRS, Hong Psychological Reactance Scale; LATCon II, Leeds Attitude Towards Concordance II Scale; MHLC-C, Multidimensional Health Locus of Control, Form C; PPOS, Patient-Practitioner Orientation Scale; SF-12, Short Form-12.