Ospemifene in the Management of Vulvar and Vaginal Atrophy: Focus on the Assessment of Patient Acceptability and Ease of Use

Figures & data

Table 1 Safety of Ospemifene and Vaginal Oestrogens on the Risk of Hormone-Dependent Cancer, Venous Thrombosis (VTE) or Cardiovascular Disease (CVD). Summary of the Literature

	Ospemifene	Vaginal Oestrogens
Endometrial Cancer	Safe	Safe
Breast Cancer	Safe	Unclear
VTE	Safe	Safe
CVD	Safe	Safe

Table 2 Risk of Side Effects, Discontinuation Rate, Adherence to, Satisfaction with and Overall Related Cost of Treatment with Ospemifene or Vaginal Oestrogens. Summary of the Literature

	Ospemifene	Vaginal Oestrogens
Hot Flushes	Slight	None/Slight
Vaginal Discharge	Slight	High
Headache	Slight	Moderate
Leg Cramps	Slight	None
Discontinuation	Slight/Moderate	High
Adherence	Moderate/High	Low
Satisfaction	High	Low
Overall Health-Related Cost	Lower	Higher