Mediating Effect Of The Motivation For Medication Use On Disease Management And Medication Adherence Among Community-Dwelling Patients With Schizophrenia

Figures & data

Figure 1 Theoretical framework of this study.

Table 1 Distribution Of Various Factors And Relationships With Medication Adherence

Factors	Data Distribution		Relationship With Adherence
	N (%)	M (SD)	Mean (SD)	t^a/r^b/F^c	p
Gender				1.32^a	0.186
Male	217 (58.2)		6.18 (2.38)
Female	156 (41.8)		5.85 (2.50)
Age		46.61 (9.09)		0.07^b	0.160
Marital status	264 (70.8)			1.62^c	0.199
Single	58 (15.5)		6.00 (2.40)
Married	51 (13.7)		5.76 (2.48)
Divorced/widower	51 (13.7)		6.57 (2.52)
Education level				1.06^c	0.347
Middle school or below	132 (35.4)		5.82 (2.40)
Senior high school	166 (44.5)		6.23 (2.47)
College and above	75 (20.1)		6.05 (2.42)
Employment status				0.03^c	0.970
Unemployment	285 (76.4)		6.03 (2.40)
Employed part-time	49 (13.1)		6.06 (2.63)
Employed full time	39 (10.5)		6.13 (2.46)
Illness duration		22.42 (9.15)		0.06^b	0.241
Number of hospitalizations		5.44 (6.20)		−0.19^b	<0.001***
Global function		69.54 (15.28)		0.17^b	0.001**
Symptoms		12.29 (7.25)		−0.18^b	0.001**
Type of antipsychotic				0.25^c	0.781
Typical	66 (17.7)		5.92(2.53)
Untypical	276 (74.0)		6.09(2.41)
Mix	31 (8.3)		5.84(2.53)
Drug formulation				1.98^c	0.140
Oral	297 (79.6)		6.13(2.44)
IM	33 (8.9)		5.24(2.40)
Mix	43 (11.5)		6.07(2.40)
Daily dose		1.45 (0.84)		0.07^b	0.151
Side effects		11.99 (10.38)		−0.12^b	0.017*
Therapeutic alliance		60.11 (14.24)		0.39^b	<0.001***
Insight		19.98 (5.52)		−0.31^b	<0.001***
Medical social support		17.94 (6.09)		0.25^b	<0.001***
Motivation for medication use		8.23 (2.19)		0.43^b	<0.001***
Medication adherence		6.01 (2.43)		-	-
Adherence	176 (47.2)			-	-
Nonadherence	197 (52.8)			-	-

Notes: ^at-test; ^bPearson’s correlation (R); ^cANOVA (F); *P < 0.05. **P < 0.01. ***P< 0.001.

Figure 2 Mediating effects of motivation for medication use on disease management related factors and medication adherence.

Table 2 Summary Of The Mediating Effects Of Motivation For Medication Use On Disease Management Related Factors And Medication Adherence

Predictors	Total Effect		Direct Effect		Indirect Effect
	β	p	β	p	β	p	Proportion Mediated
Therapeutic alliance	0.345	<0.001	0.172	0.007	0.173	<0.001	50%
Insight	−0.278	<0.001	−0.164	0.004	−0.114	<0.001	41%
Medical social support	0.201	<0.001	0.056	0.289	0.145	<0.001	72%

Note: Proportion mediated (%) = indirect effect/total effect.