Validity Of The Self-Reported Domains Of Subjective Extent Of Nonadherence (DOSE-Nonadherence) Scale In Comparison With Electronically Monitored Adherence To Cardiovascular Medications

Figures & data

Table 1 Characteristics Of Study Participants

		M (SD) or %
		Overall (N=165)	English Speaking (n=68)	Spanish Speaking (n=97)
Age in years		61.87 (11.16)	60.10 (11.43)	63.10 (10.78)+
Sex	Male	54.55%	57.35%	47.42%
	Female	45.45%	42.65%	52.58%
Race	Black	18.79%	42.65%	2.06%**
	White	8.48%	16.18%	3.09%
	Other	72.73%	41.17%	94.85%
Ethnicity	Hispanic	66.67%	29.41%	92.78%
	Non-Hispanic	34.33%	70.59%	7.22%
Education	High school or Less	60.00%	39.71%	74.23%**
	Trade school/some college	16.97%	26.47%	10.31%
	College degree	12.73%	11.76%	13.40%
	Graduate degree	10.30%	22.06%	2.06%
English as a first language	No	58.79%
	Yes	41.21%
Confirmed ACS	Yes	33.33%	35.29%	31.96%
	No	66.67%	64.71%	68.04%

Notes: +P<0.10, **P<0.01.

Figure 1 Comparison of adherence classification by the 3-item extent of nonadherence questionnaire with electronically monitored adherence, stratified by participant language.

Note: Medications were electronically monitored using eCAPs (English speaking, n=68; Spanish speaking, n=97).

Table 2 Sensitivity, Specificity, And Likelihood Ratios (LRs) Of The Extent Of Nonadherence Questionnaire For Detecting Medication Nonadherence

	Sensitivity	Specificity	LR+	LR-
	Est [95% CI]	Est [95% CI]	Est [95% CI]	Est [95% CI]
Overall (N=165)	0.35 [0.26, 0.45]	0.83 [0.71, 0.91]	2.02 [0.80, 3.24]	0.78 [0.64, 0.93]
English-speaking (n=68)	0.47 [0.31, 0.64]	0.77 [0.58, 0.90]	2.03 [0.52, 3.54]	0.69 [0.43, 0.94]
Spanish-speaking (n=97)	0.28 [0.18, 0.41]	0.88 [0.72, 0.97]	2.32 [0.00, 4.67]	0.82 [0.65, 0.98]

Notes: Any (vs no) self-reported nonadherence over the past 7 days on the extent of nonadherence questionnaire indicated a positive screen. <100% (vs 100%) adherence over the past 7 days, as electronically monitored by eCAPs, indicated a true positive for nonadherence.