Fixed combination of lercanidipine and enalapril in the management of hypertension: focus on patient preference and adherence

Figures & data

Table 1 Effect of fixed association of enalapril–lercanidipine on blood pressure control

Reference	Patients, n	Duration	Intervention	Outcome
Agrawal et al^Citation57	174	20 weeks	Lercanidipine + enalapril 20 mg versus hydrochlorothiazide + enalapril 20 mg	SBP −9.6 versus −6.0 mmHg DBP −9.3 versus −7.4 mmHg
Recordati SpA^Citation58	338	12 weeks	Enalapril 20 mg versus lercanidipine 10 mg + enalapril 20 mg	SBP −6.7 versus −9.8 mmHg DBP −7.5 versus −9.2 mmHg
Recordati SpA^Citation59	337	12 weeks	Lercanidipine 10 mg versus lercanidipine 10 mg + enalapril 10 mg	SBP −2.3 versus −7.7 mmHg DBP −4.3 versus −7.1 mmHg
Puig et al^Citation60	75	4 months	Lercanidipine10 mg versus enalapril 20 mg alone or in combination versus placebo	SBP −5 versus −5.9 versus 16.9 mmHg, versus placebo
Rump^Citation61	8440	3 months	Enalapril 10 mg + lercanidipine 10 mg or enalapril 10 mg + lercanidipine 20 mg	SBP −28.4 mmHg DBP −13.5 mmHg
Gil Guillén et al^Citation65	1562	6 months	Lercanidipine + enalapril 20 mg alone or in combination	SBP −25.4 mmHg DBP −13.6 mmHg

Abbreviations: SBP, systolic blood pressure; DBP, diastolic blood pressure.

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